Tirzepatide for MASLD in Patients with Obesity

This study is looking at how a medication called Tirzepatide affects the liver in people who have Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and obesity. MASLD is a common liver condition often linked to being overweight or having obesity. Tirzepatide is already used for type 2 diabetes and obesity, and it has shown promise for MASLD. Researchers will measure changes in MASLD-related markers after 12 months to see if Tirzepatide helps. You may be able to join if you are between 18 and 75 years old, have MASLD, and meet certain criteria related to your BMI, waist size, or blood sugar levels. The current recruitment status is unclear.

Study design
This is an interventional study with a planned enrollment of 8 participants. The study is investigating the effects of Tirzepatide.
What's involved
You would take Tirzepatide for 12 months. You would have clinic visits every 3 months, blood draws at baseline, 6, and 12 months, and liver ultrasounds at baseline and 12 months.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured at 12 months, which is the duration of the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06934642

Effect of Tirzepatide on Markers of MASLD in Patients With Obesity

Recruiting
EARLY_PHASE1Ages 18–75Interventional
University of New Mexico
~8 participants
Updated 2026-07-15 on ClinicalTrials.gov
What's tested:Tirzepatide

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Biomarkers associated with MASLD
Measured over 12 months
MASLD
Obesity
1 sites across 1 states
New Mexico1
  • Eliseo Castillo · PRINCIPAL_INVESTIGATOR · UNM Cancer Center

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Men and women
Age 18-75
Diagnosis of MASLD based on the following criteria:
Presence of at least 1 out of the 5 following cardiometabolic criteria:
BMI \>25 kg/m2 OR waist circumference \>94 cm (men) or 80cm (women)
Fasting serum glucose \>100 mg/dL OR 2-hour post-prandial glucose levels \>140mg/dL OR AbA1c \>5.7% OR type 2 diabetes OR treatment for type 2 diabetes
Blood pressure \>130/85 mmHg OR specific antihypertensive drug treatment
Plasma triglycerides \>150mg/dL OR on lipid lowering treatment
Plasma HDL-cholesterol \<40mg/dL (men) and \<50mg/dL (women) OR on lipid lowering medication
No other identified causes of steatosis
Evidence of steatotic liver disease (hepatic steatosis identified by imaging or biopsy)
English speaking

Exclusion

Pregnancy or breast feeding
Premenopausal women not on any form of contraception
Reports alcohol intake \>50g/day or 350g/week for women and \>60g/day or 420g/week for men or an AUDIT score \>8
Other identifiable causes of steatosis
Documented allergic reaction to tirzepatide or any other GLP1 RA
Decompensated liver disease
Decompensated renal disease requiring hemodialysis
Decompensated heart failure
Active malignancy
Prior history of pancreatitis
Serum triglyceride levels \>500 mg/dL
Personal or family history of medullary thyroid cancer or MEN2a or MEN2b
Concurrent use of other ant-obesity medications
Use of other GLP1 RAs within 3 months of study enrollment
Unable to obtain the medication due to cost or insurance coverage restrictions.
  • Biomarkers associated with MASLD12 months

    Identification of an changes in biomarkers associated with MASLD with tirzepatide use