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Early Semaglutide Re-Initiation After Sleeve Gastrectomy in Youth

This study is for young people aged 12 to 18 with severe obesity who are having sleeve gastrectomy (a type of weight-loss surgery). It's looking at whether restarting semaglutide (a medication) two weeks after surgery, compared to standard care without medication, helps maintain weight loss. You would have been taking semaglutide 2.4 mg weekly for at least 3 months before surgery to join. The study will follow 150 participants for 24 months to see how their Body Mass Index (BMI) changes. The current status of this study is unclear.

Study design
This is a Phase 3a randomized controlled trial, meaning participants are randomly assigned to one of two groups. It plans to enroll 150 youth.
What's involved
You would have blood collected before and after surgery at specific times. Assessments will occur at 1 month before surgery, on the day of surgery, and then at 1, 3, 6, 9, 12, 18, and 24 months after surgery.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 24 months after surgery to assess outcomes.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06934655

Early Reinitiation of Semaglutide Post-Sleeve Gastrectomy in Youth

Recruiting
PHASE3Ages 12–18InterventionalTreatment
Children's Hospital Los Angeles
~150 participants
Updated 2026-09-02 on ClinicalTrials.gov
What's tested:Semaglutide 2.4 mg

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percent Body Mass Index
Measured over From enrollment to the end of the end of the study at 24 months

Conditions

Pediatric Obesity
Metabolic and Bariatric Surgery
Semaglutide

Explore related trials

Obesity

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Alaina Vidmar, MD · PRINCIPAL_INVESTIGATOR · Children's Hospital Los Angeles

Who to contact

Alaina P Vidmar, MD
[email protected]
530-383-1732
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

ages 12 to 18 years
Tanner stage 3 or higher
severe obesity (defined as a BMI greater than 35 kg/m2 or BMI ≥140% of the 95th percentile)
currently undergoing primary surgical weight loss through the pediatric bariatric surgery pathway at Children's Hospital Los Angeles
be willing to have blood collected before and after surgical procedure at defined points
be willing to have clinical data entered into a prospective database; 8) presence of a consenting caregiver
be taking semaglutide 2.4 mg weekly as part of their routine medical care prior to surgery as part of their obesity treatment program, apart from any planned surgical procedure.

Exclusion

have a previous diagnosis of type 1 diabetes
taking any medications known to influence body composition or prevent weight loss or promote weight gain (e.g. prednisone)
have been diagnosed with syndromes or diseases that may influence the postoperative course (e.g., Cushing syndrome, Down syndrome, Prader Willi Syndrome)
have significant comorbid medical conditions necessitating frequent hospitalization that may require interruption of medications and/or that would make early re-initiation of semaglutide unsafe due to the other medical comorbidities
refuse to comply with eligibility criteria.

What this trial measures

  • Percent Body Mass IndexFrom enrollment to the end of the end of the study at 24 months

    Percent Body Mass Index (%BMI) is calculated as the participant's BMI at each assessment time point expressed as a percentage of the 95th percentile BMI for age and sex, based on CDC growth charts. This metric is commonly used in pediatric populations to more accurately reflect degrees of obesity in youth, particularly at the upper end of the BMI distribution where standard BMI z-scores may lose sensitivity. Calculation Formula: %BMI = (Participant's BMI / 95th percentile BMI for age and sex) × 100 Type (continuous) Units (Percent) Justification: %BMI is used as a more precise and interpretable measure of adiposity in children and adolescents with severe obesity. It allows for consistent tracking of obesity severity and treatment response over time, even in populations whose BMI values significantly exceed the 95th percentile.