Bupivacaine Injections vs. IV Medications for Headache Treatment

This study is comparing two ways to treat headaches in the emergency room: an injection of 0.5% Bupivacaine HCl into the neck muscles, or standard intravenous (IV) medications chosen by the doctor. The goal is to see which treatment works better for pain relief. You might be able to join if you are 18 or older, speak English, and have a non-traumatic headache with a pain level of 5 or higher out of 10. You cannot join if you have certain conditions like an allergy to bupivacaine, a bleeding disorder, or are pregnant. The study will measure your pain level 24 hours after treatment to see how well each method worked. The current status of this study is unclear, and it plans to enroll 100 participants.

Study design
This interventional study plans to enroll 100 participants to compare two headache treatments. It is not specified if it is randomized or blinded.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants' pain levels will be measured 24 hours after treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06937385

0.5% Bupivacaine Lower Cervical Intramuscular Injection vs IV Medications for Headache Treatment

Not Yet Recruiting
PHASE3Ages 18+InterventionalTreatment
HCA Florida North Florida Hospital
~100 participants
Updated 2025-04-24 on ClinicalTrials.gov
What's tested:0.5% Bupivacaine HClstandard IV treatment for headache

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Visual analog scale pain score 0-10
Measured over 24 hours
Headache
Migraine
Tension Headache
Occipital Neuralgia
1 sites across 1 states
Florida1
  • Robyn Hoelle, MD · PRINCIPAL_INVESTIGATOR · HCA north florida hospital emergency department

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Eligibility criteria

Inclusion

Patient has to be able to provide own consent
English-speaking only
Non traumatic headache with VAS pain score of 5 or above out of 10

Exclusion

traumatic headache
Confused patients
allergy to bupivacaine
infection over injection site
recent neck surgery
hemodynamically unstable
bleeding disorder
anticoagulation use
pregnant, lactating women
prisoners
  • Visual analog scale pain score 0-1024 hours

    Pain score at 30 minutes and 24 hours after treatment. 0 being no pain and 10 being the worse pain possible.