Topical Timolol for Healing Surgical Wounds

This study is looking at whether a topical solution called Timolol 0.5% can help speed up the healing of open wounds after Mohs Micrographic Surgery (a precise surgical method used to treat skin cancer). Currently, there isn't much research on using Timolol for these types of fresh surgical wounds. You might be able to join if you are at least 18 years old, speak English, and are scheduled for Mohs surgery for a skin cancer that will leave an open wound between 0.5 cm and 4 cm. The study will compare healing in people who use Timolol 0.5% solution to those who use Vaseline. Researchers will measure how much the wound surface area heals over 12 weeks to see if Timolol is effective. The current status of this study is unclear.

Study design
This is an interventional study planning to enroll 102 participants. It compares the effects of Timolol 0.5% solution to standard care (Vaseline) on wound healing.
What's involved
You would apply either Timolol 0.5% solution or Vaseline to your wound daily. The number of drops of Timolol would be based on your initial wound size and remain constant until the wound heals. You would have visits or photo checks at 2, 4, 6, and 12 weeks.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for wound healing for 12 weeks after starting treatment.

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NCT06941467

Topical 0.5% Timolol Solution for Healing Lower Extremity Wounds

Recruiting
PHASE1Ages 18+InterventionalTreatment
Icahn School of Medicine at Mount Sinai
~102 participants
Updated 2025-04-23 on ClinicalTrials.gov
What's tested:Timolol Maleate SolutionStandard of Care

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Wound surface area healing (skin reepithelialization)
Measured over 2 weeks, 4 weeks, 6 weeks, 12 weeks
Wound Healing
Mohs Micrographic Surgery
1 sites across 1 states
New York1
  • Jesse Lewin, MD · PRINCIPAL_INVESTIGATOR · Primary Investigator

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Be scheduled to undergo MMS at 234 East 85th St for a skin cancer that is deemed Mohs
Appropriate by the Mohs surgery appropriate use criteria
Have an open surgical wound \< 4 cm and \> 0.5 cm
Be ≥18 years of age
English-speaking
Provide a signed and dated informed consent form
State willingness to comply with all study procedures

Exclusion

Age less than 18 years of age
Open surgical wound \> 4 cm
If tumor clearance cannot be achieved with MMS
Pregnant women
Breastfeeding women
Patients who are taking oral beta-blockers (ie oral timolol, metoprolol, carvedilol, propranolol, atenolol)
Patients who are currently taking any of the following medications: clonidine, digoxin, methyldopa, quinidine, fluoxetine and paroxetine, bupropion
Patient currently taking a calcium channel blocker AND has pre-existing heart failure as defined by a reduced ejection fraction
Patients with pre-existing hypotension
Pre-existing diagnosis of sinus bradycardia
Pre-existing diagnosis of second or third degree atrioventricular block
Congestive heart failure
Pre-existing diagnosis of severe asthma
Pre-existing diagnosis of chronic obstructive pulmonary disease
Any known hypersensitivity to 0.5% timolol solution
Patients who have a wound where primary closure is feasible and desired by the patient
Defect size \<0.5 cm
Prior sensitivity or known allergy to timolol
  • Wound surface area healing (skin reepithelialization)2 weeks, 4 weeks, 6 weeks, 12 weeks

    The wound surface area healing (skin reepithelialization) in open post-surgical lower extremity wounds will be measured using a ruler.