Efanesoctocog Alfa for Hemophilia A with Joint Swelling

This study is looking at how well a medicine called efanesoctocog alfa helps people with moderate to severe hemophilia A (a bleeding disorder where your blood doesn't clot properly) who have swelling in their joints. The study will give efanesoctocog alfa once a week through an IV (into a vein) for about 12 months. Researchers want to see if this treatment improves joint swelling, which will be measured using a special ultrasound test. You can join if you are 12 years or older and have moderate to severe hemophilia A. The study plans to enroll 35 participants, but its current recruitment status is unclear.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 35 participants.
What's involved
You would receive efanesoctocog alfa once a week through an IV for approximately 12 months. Your joint swelling will be checked with an ultrasound during this time.
Compensation
Not stated in the trial record.
Follow-up
Your joints will be checked for improvement from the start of the study up to Week 52 (about 12 months).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06941870

Efanesoctocog Alfa Prophylaxis in Patients With Hemophilia A With Synovial Hypertrophy

Recruiting
PHASE4Ages 12+InterventionalTreatment
Sanofi
~35 participants
Updated 2025-11-18 on ClinicalTrials.gov
What's tested:Efanesoctocog alfa

At a glance

Recruiting sites
13 of 13 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Proportion of joints with improvement in the Hemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) synovitis domain score
Measured over From Baseline up to Week 52
Factor VIII Deficiency
13 sites across 8 states
Japan3
Taiwan3
Ontario2
California1
Indiana1
Iowa1
Ohio1
Kanagawa1
Trial Transparency email recommended (Toll free for US & Canada)
Email the study team

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  • Proportion of joints with improvement in the Hemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) synovitis domain scoreFrom Baseline up to Week 52

    HEAD-US scoring system is a simplified ultrasound scanning procedure to image the elbow, knee, and ankle (index joints) and a scoring system based on an additive scale to define the joint status from disease activity and disease damage parameters to evaluate disease progression and monitor the results of treatment.