This study is exploring whether ketamine can help reduce cravings for opioids in adults who are starting methadone treatment for opioid use disorder. Researchers will compare two different low doses of ketamine: 0.75 mg/kg and 0.1 mg/kg. You might be able to join if you are 18-65 years old, have recently used illicit opioids, meet criteria for moderate-to-severe opioid use disorder, and have started methadone treatment within the last 21 days. The main goal is to see if ketamine reduces opioid cravings, but researchers will also look at how it affects withdrawal symptoms like depression, pain, and sleep, and if it helps people stay in methadone treatment longer. The study plans to enroll 50 participants.

Study design

This interventional study will compare two different low doses of ketamine in 50 participants.

What's involved

Participants will receive four doses of ketamine over two weeks, with each session requiring two hours of monitoring by a clinician. You will also have assessments at baseline, weekly, and at 30, 60, and 90 days after starting the study.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed for 90 days after starting the study to measure opioid cravings and other outcomes.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.