Potassium Citrate and Kidney Stones Study
This study at the University of Chicago aims to understand how two substances, oxalate and citrate, interact in your body and might affect kidney stone formation. Researchers are testing how levels of oxalate and citrate in your urine change after you drink a special solution containing potassium citrate. They are looking for changes in these levels at 2, 4, and 6 hours after you drink it. You may be able to join if you are between 18 and 70 years old and have a history of calcium-based kidney stones, or if you have never had kidney stones and your 24-hour urine oxalate levels are normal. The study plans to enroll 24 participants.
- Study design
- This is a single-center study involving 24 participants, divided into two groups: those with kidney stones and those without. All participants will receive potassium citrate.
- What's involved
- You will collect urine at home the day before your visit. Then, you will spend a full day at the University of Chicago research clinic, consuming a special drink (potassium citrate).
- Compensation
- Not stated in the trial record.
- Follow-up
- Your urine and blood will be measured over six hours after consuming potassium citrate.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Oxalate and Citrate in Humans - Response to Citrate
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
Opens a ready-to-send draft in your own email app — review before sending.
Do you actually qualify for this trial?
Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.
Inclusion
What this trial measures
- Change in urine oxalate from baseline to 2-hours, 4-hours, and 6-hours after potassium citrate consumption.6 hours
Urine oxalate will be measured or calculated at time points 0, 2-hours, 4-hours, and 6-hours after sodium oxalate consumption. We will compare change in urine citrate and fractional excretion of citrate by change in oxalate at each time period for all participants.
- Change in urine citrate from baseline to 2-hours, 4-hours, and 6-hours after potassium citrate consumption.6 hours
Urine citrate will be measured or calculated at time points 0, 2-hours, 4-hours, and 6-hours after sodium oxalate consumption. We will compare change in urine citrate and fractional excretion of citrate by change in oxalate at each time period for all participants.
- Change in fractional excretions of citrate and oxalate from baseline to 2-hours, 4-hours, and 6-hours after potassium citrate consumption.6 hours
Fractional excretion of citrate will be measured or calculated at time points 0, 2-hours, 4-hours, and 6-hours after sodium oxalate consumption. We will compare change in urine citrate and fractional excretion of citrate by change in oxalate at each time period for all participants.