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Pumpkin Seed Oil Extract for Overactive Bladder

This study is looking at how a dietary supplement called Pumpkin Seed Extract might help women who experience overactive bladder (OAB). OAB can cause frequent and urgent trips to the bathroom. Researchers want to see if taking 1000mg of Pumpkin Seed Extract daily for 12 weeks can improve bladder function. They will measure changes using a survey called the LURN-SI (Lower Urinary Tract Dysfunction Network Symptom Index-10). You might be able to join if you are a woman, 18 or older, and have symptoms of overactive bladder, and are willing to take a dietary supplement.

Study design
This is a pilot study planning to enroll 40 women. It is an interventional study, meaning participants will receive the Pumpkin Seed Extract.
What's involved
You would take the Pumpkin Seed Extract daily for 12 weeks. Your bladder function would be assessed at the beginning, after 4 weeks, and again at 12 weeks using surveys.
Compensation
Not stated in the trial record.
Follow-up
Your bladder function will be assessed at 12 weeks after starting the supplement.

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NCT06944392

Evaluating Pumpkin Seed Oil Extract Supplementation on Bladder Function

Recruiting
NAAges 18+InterventionalSupportive care
Northwestern University
~40 participants
Updated 2026-04-23 on ClinicalTrials.gov
What's tested:Pumpkin Seed Extract

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
LURN-SI
Measured over 12 weeks

Conditions

Overactive Bladder (OAB)

Explore related trials

Overactive Bladder

Where it's being run

1 sites across 1 states
Illinois1

Who to contact

Julia Geynisman-Tan, MD
[email protected]
312-926-9929
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Eligibility criteria

Inclusion

All patients evaluated at Northwestern's IPHP who report bladder function consistent with overactive bladder (urinary urgency, with or without urinary frequency more than 8 times daily or nocturia, with or without urgency urinary incontinence) at their index visit, who are also willing to use a dietary supplement and not initiate additional behavioral, medication or procedural treatment for 12 weeks following pumpkin seed oil extract initiation.

Exclusion

Patients with any of the following will be excluded from the study:
Use of other supplements that contain pumpkin seed oil
≥Stage 3 pelvic organ prolapse
Urinary post-void residual ≥150cc
Culture-proven urinary tract infection at time of study enrollment
Recurrent urinary tract infection
Neurogenic bladder
Abdominal or pelvic malignancy
Initiation of new overactive bladder medications or supplements during study period or in the 3 months immediately preceding study enrollment
History of surgery in the past 12 months for pelvic organ prolapse, stress urinary incontinence, urgency urinary incontinence, or fecal or flatal incontinence
Patient's primary language is not English

What this trial measures

  • LURN-SI12 weeks

    Assess changes in patient-reported bladder function reflected through their responses on the LURN-SI survey.