Stepped Care for Posttraumatic Stress Disorder Study

This study is testing different ways to help people with Post Traumatic Stress Disorder (PTSD). It compares several behavioral treatments: webSTAIR (an online program), webSTAIR plus coaching, Brief STAIR (a short therapy with a clinician), and Written Exposure Therapy (WET, another short therapy with a clinician). The study aims to see how well these treatments reduce PTSD symptoms, how many people stay in treatment, and how acceptable the treatments are. You might be able to join if you are at least 18, a Boston Medical Center primary care patient, have access to a computer or mobile device, can receive treatment in English or Spanish, and have a PTSD diagnosis. The study plans to enroll 428 participants.

Study design
This study is an interventional study that will enroll 428 participants. It uses a special design where participants are first assigned to one treatment, and if their symptoms don't improve enough, they are then assigned to a different treatment.
What's involved
You would participate in online modules or individual sessions for up to 30 weeks. Your PTSD symptoms and how you feel about the treatment will be checked at different times.
Compensation
Not stated in the trial record.
Follow-up
Your PTSD symptom severity, treatment retention, and treatment acceptability will be measured up to 30 weeks.

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NCT06947538

Stepped Care for Posttraumatic Stress Disorder Study

Recruiting
NAAges 18+InterventionalTreatment
Boston Medical Center
~428 participants
Updated 2026-07-14 on ClinicalTrials.gov
What's tested:webSTAIRWebSTAIR plus coachingClinician administered Brief STAIRClinician administered WET

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
PTSD symptom severity
Measured over baseline, 4 weeks, 8 weeks, 18 weeks, 30 weeks
+2 more outcomes measured
Post Traumatic Stress Disorder
1 sites across 1 states
Massachusetts1
  • Sarah Valentine, PhD · PRINCIPAL_INVESTIGATOR · Boston Medical Center, Psychiatry

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Eligibility criteria

Inclusion

Boston Medical Center primary care patient
At least 18 years of age
Access to computer or mobile device
Able to receive treatments in English or Spanish
Able to read at 4th grade level
Endorsement of Criterion A trauma using the Life Events Checklist for the DSM-5 (LEC-5), assessed at baseline
PTSD diagnosis, confirmed by the Clinician-Administered PTSD Scale for the DSM-5 (CAPS-5) assessed at baseline
Clinically appropriate for outpatient level of care
Stable on psychotropic medication for \>4 weeks

Exclusion

Patient is not clinically appropriate for outpatient level of care.
Acute risk for suicidal thoughts or behaviors, assessed by the Columbia Suicide Severity Rating Scale, administered by research clinician at baseline.
  • PTSD symptom severitybaseline, 4 weeks, 8 weeks, 18 weeks, 30 weeks

    This outcome will be assessed by the PTSD Checklist for the DSM-5 (PCL-5), a 20-item self-report measure that evaluates the degree to which individuals have been bothered by PTSD symptoms in the past month tied to their most distressing event. Total scores ranging from 0 to 80, and a score of 31-33 or higher suggests probable PTSD and potential benefit from treatment.

  • Treatment retention4 weeks, 8 weeks, 18 weeks

    as the proportion (%) of participant who complete 60% of interventions in the treatment windows.

  • Treatment acceptability4 weeks, 8 weeks, 18 weeks, 30 weeks

    This outcome will be assessed with the Client Satisfaction Questionnaire 8 \[CSQ-8\], a 8-item instruction where scores are summed across items once. Items 2, 4, 5, and 8 are reverse scored. Total scores range from 8 to 32, with the higher number indicating greater satisfaction.