Smoking Cessation with E-Cigarettes and Nicotine Therapy for Obese Smokers

This study is looking at how electronic cigarettes (EC) and nicotine replacement therapy (NRT) can help people who smoke and also have obesity (BMI of 30 or higher) to quit smoking. You would be asked to switch to either EC or NRT for 8 weeks, and these products would be provided. Researchers will compare how well EC and NRT help people reduce or quit smoking, looking at things like the number of cigarettes smoked per day and carbon monoxide (CO) levels in your breath. They will also look at how these interventions affect your weight and other health factors. To join, you must be at least 21 years old, smoke at least 5 cigarettes a day, and have a high CO level in your breath. The study plans to enroll up to 60 participants.

Study design
This interventional study will randomly assign up to 60 participants to receive electronic cigarettes, nicotine replacement therapy, or a no-product control for 8 weeks.
What's involved
You would be asked to use either electronic cigarettes or nicotine replacement therapy for 8 weeks. Assessments will occur at baseline, and at 1, 2, and 3 months after starting the study.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 3 months after starting the study interventions.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06948058

Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine Therapy

Recruiting
NAAges 21+InterventionalTreatment
Brown University
~60 participants
Updated 2026-05-18 on ClinicalTrials.gov
What's tested:Electronic Cigarettes (EC)Nicotine replacement therapy (NRT)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
number of cigarettes per day
Measured over 2 months
+2 more outcomes measured
Smoking Cessation
Obesity and Obesity-related Medical Conditions
1 sites across 1 states
Rhode Island1

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

body mass index (BMI) ≥ 30 kg/m2 (i.e., obese)
smoked ≥ 5 cigarettes/day during the past year
21 or older (due to minimum legal age EC restrictions)
exhaled breath carbon monoxide (CO) level \> 6 ppm at Baseline (BL) (to confirm self-reported smoking)
willing to use EC or NRT for 8 weeks
access to a Bluetooth-enabled smartphone/tablet (to permit remote measurement of CO and other outcome variables)

Exclusion

received smoking cessation treatment of any kind in the past 30 days (actively quitting smoking),
currently using EC or NRT more than 2 days/week (this may affect responses to study-supplied products)
hospitalized for mental illness in past 30 days
heart-related event (e.g., heart attack, severe angina) in past 30 days
residing with another person currently enrolled in the study
pregnant, nursing, or planning to become pregnant in the next 6 months
medical contraindication for study or product use (e.g., allergy to adhesives)
taken prescription weight loss medication in the last 30 days
  • number of cigarettes per day2 months

    Daily use of cigarettes will be determined using the Timeline Follow-Back (TLFB) in follow-up assessments.

  • carbon monoxide (CO)2 months

    Exhaled breath sample used to measure carbon monoxide

  • number of quit attempts2 months

    Number of attempts to quit smoking during the experimental period