Orforglipron for High Blood Pressure with Obesity or Overweight

This study is testing a medicine called Orforglipron (LY3502970) in people who have high blood pressure (hypertension) and are also overweight or have obesity. Researchers want to see if Orforglipron is safe and if it can help lower blood pressure. Some participants will receive Orforglipron, and others will receive a placebo (an inactive substance like a sugar pill). The main thing researchers will measure is how much your systolic blood pressure (the top number in a blood pressure reading) changes from the start of the study to Week 36. Adults aged 18 and older can potentially join. The current status of this study is unclear.

Study design
This is an interventional study planning to enroll 487 participants. It compares Orforglipron to a placebo.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for changes in blood pressure up to Week 36.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06948435

A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL1

Active, Not Recruiting
PHASE3Ages 18+InterventionalTreatment
Eli Lilly and Company
~487 participants
Updated 2026-05-29 on ClinicalTrials.gov
What's tested:OrforglipronPlacebo

At a glance

Recruiting sites
0 of 99 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change from Baseline in office Systolic Blood Pressure (SBP)
Measured over Baseline to Week 36
Hypertension
Overweight or Obesity
99 sites across 28 states
China12
Argentina9
Czechia9
Germany9
Poland8
Spain7
Greece6
Japan5
  • Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST) · STUDY_DIRECTOR · Eli Lilly and Company

This trial hasn't published a contact. View it on ClinicalTrials.gov

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Eligibility criteria

Inclusion

refer to the GZPL master protocol for screening eligibility.

Exclusion

refer to the GZPL master protocol for screening eligibility.
  • Change from Baseline in office Systolic Blood Pressure (SBP)Baseline to Week 36