Metabolic Health, Bones and Nuts During Weight Loss in Adults

This study is looking at how eating peanuts might affect bone health and overall metabolic health (like blood sugar and fats) during weight loss in older adults. Researchers want to see if a daily peanut snack, compared to a nut-free snack, can help improve bone mineral density (BMD) in the hip. You could be eligible if you are between 50 and 75 years old, are a man or a postmenopausal woman, and have a Body Mass Index (BMI) between 25 and 42 (indicating overweight or obesity). The study plans to enroll 44 participants, but its current status is unclear.

Study design
This is an interventional study that aims to enroll 44 participants. You would be randomly assigned to either receive a daily peanut snack or a nut-free snack.
What's involved
You would need to attend about 10 on-site visits in New Brunswick, NJ, USA, over 24 weeks. You would also receive nutrition education and behavior modification instructions for weight loss.
Compensation
Reimbursement for travel is not included.
Follow-up
Your bone mineral density (BMD) in the hip will be measured at 24 weeks from the start of the study.

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NCT06949280

Metabolic Health, Bones and Nuts During Weight Loss in Adults

Recruiting
NAAges 50–75InterventionalTreatment
Rutgers, The State University of New Jersey
~44 participants
Updated 2026-05-13 on ClinicalTrials.gov
What's tested:Peanut Snack ExperimentalNut-free Snack

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Bone Mineral Density (BMD - hip)
Measured over Change from baseline to 24 weeks
Weight Loss
Bone Density
Obesity and Overweight
1 sites across 1 states
New Jersey1

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Eligibility criteria

Inclusion

Men and postmenopausal women (\>2 years since last menses), ages 50-75 years
Body mass index (25-42 kg/m2) or evidence of pre-clinical obesity.
Agree to be randomly assigned to consume a daily peanut snack or nut-free snack for 24 weeks
Must attend on-site visits (about 10) in New Brunswick, NJ, USA (transportation/reimbursement for travel not included)

Exclusion

Peanut allergies or intolerances
Participants with \>5% weight loss in the past 6 months or extreme dietary/physical activity habits
An inability to follow the experimental intervention or to perform the required specimen collections.
Individuals with significant psychiatric or food disorders.
Current diagnosis, or history of cancer in past 3 years.
Current diagnosis or history of bone diseases, type I or II diabetes, gastrointestinal disease, hyperparathyroidism, untreated thyroid disease, significant immune, hepatic, cardiac, or renal disease.
Uncontrolled hypertension or hyperlipidemia in abnormal ranges.
History of surgery in the past 6 months or surgical procedure for weight loss in the past 3 years.
Regular use of medications that affect bone metabolism, including bisphosphonates or hormone replacement.
Regular use of medications for that affect the gastrointestinal tract including incretin mimetics, cholecystitis, urinary tract infection, severe organic diseases including coronary heart disease, myocardial infarction, infectious diseases including pulmonary tuberculosis and AIDS.
Antibiotic use in the past month
Alcohol or illicit drug abuse
Any other condition deemed by the Research Physician that would prevent participation in the study, e.g. participation in another clinical research project that may interfere with the results of this study.
Participation in another clinical interventional research trial
  • Bone Mineral Density (BMD - hip)Change from baseline to 24 weeks

    dual energy x-ray absorptiometry; g/cm2