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NCT06950060

AMPLIFI: Adaptive Modulation of Plasticity Through Lactate and Fitness Interventions

Active, Not Recruiting
NAAges 18–85InterventionalBasic science
University of Alabama at Birmingham
~48 participants
Updated 2026-07-17 on ClinicalTrials.gov
What's tested:High intensity cyclingLow-intensity cyclingHealth education sessionModerate Intensity Aerobic Exercise

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Motor Learning Performance (12-Digit Serial Reaction Time Task)
Measured over Baseline, Day 2, Day 3, Day 4, and Day 5

Conditions

Stroke, Chronic
Aging
Cognitive Decline
Motor Dysfunction
Neuroplasticity

Explore related trials

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NCT06950060

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • CH19 933 19th St S

    Birmingham, Alabamano site contact published

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Keith McGregor, PhD · PRINCIPAL_INVESTIGATOR · Keith McGregor

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Want this trial checked against your situation?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Able to provide informed consent
Right-handed (for TMS consistency)
English-speaking
Clearance for moderate-intensity aerobic exercise
Able to safely sit and pedal a stationary cycle ergometer
No contraindications to TMS (e.g., no metal in skull, pacemakers, or seizure history)
No history of neurological or psychiatric conditions
Not currently on medications that affect the central nervous system
No diagnosis of dementia
Independent in activities of daily living
No stroke history
At least 6 months post-stroke (chronic phase)
Medically stable and cleared for aerobic exercise
Able to engage in motor learning task (with or without hemiparetic adaptations)

Exclusion

History of epilepsy or seizures
Current substance abuse or uncontrolled psychiatric disorder
Severe cardiovascular disease or unstable medical condition
Pregnancy
Contraindications to TMS or exercise testing (e.g., implanted neurostimulators, severe hypertension)
Participation in another interventional trial within the past 30 days

What this trial measures

  • Motor Learning Performance (12-Digit Serial Reaction Time Task)Baseline, Day 2, Day 3, Day 4, and Day 5

    Motor learning is assessed using the 12-digit Serial Reaction Time Task (SRTT), a computer-based measure of implicit motor sequence learning. Participants respond to visual cues by pressing buttons in a fixed or random sequence. Learning is quantified by changes in reaction time and accuracy across structured and unstructured trials. A learning index is derived by comparing performance between patterned (learning) and random sequences.