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High-Intensity Interval Training Before Stem Cell Transplant

This study is looking at how a remotely monitored high-intensity interval training (REMM-HIIT) program affects people preparing for a hematopoietic stem cell transplant (a procedure that replaces damaged blood-forming cells with healthy ones). You might be able to join if you are between 18 and 80 years old, can read and write English, and are scheduled for an allogeneic stem cell transplant within 4 to 12 weeks. The researchers want to see if REMM-HIIT improves your cardiorespiratory fitness (how well your heart and lungs work) and physical function (like your walking ability). They will compare participants who do the training to those who don't. The study aims to enroll 126 people.

Study design
This interventional study plans to enroll 126 participants. It will compare a group doing REMM-HIIT to a control group who do not train.
What's involved
If you participate, you would engage in three 30-minute training sessions per week. Your cardiorespiratory fitness and physical function will be measured at several points over a year.
Compensation
Not stated in the trial record.
Follow-up
Your cardiorespiratory fitness will be measured at baseline, Day -10, Day 90, and Day 365. Your physical function will be measured at baseline, Day -10, Day 30, Day 90, Day 180, and Day 365.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06953648

Remotely Monitored, Mobile Health-supported, High Intensity Interval Training Before Hematopoietic Stem Cell Transplant

Not Yet Recruiting
NAAges 18–80InterventionalSupportive care
University of Kansas Medical Center
~126 participants
Updated 2025-05-01 on ClinicalTrials.gov
What's tested:High Intensity Interval Training

At a glance

Recruiting sites
0 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Cardiorespiratory Fitness
Measured over At Baseline, Day -10, Day 90, and Day 365
+1 more outcome measured

Conditions

Hematopoietic Stem Cell Transplantation
Cardiorespiratory Fitness

Explore related trials

Hematopoietic Cell Transplantation

Where it's being run

3 sites across 3 states
Kansas1
North Carolina1
Texas1

Study leadership

  • Anthony Sung, MD · PRINCIPAL_INVESTIGATOR · The University of Kansas Cancer Center

Who to contact

Anthony Sung
[email protected]
913-588-6030
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Plan to undergo allogeneic hematopoietic stem cell transplant in 4-12 weeks after enrollment on this study.
Age 18-80 years
Able to read/write English (as many participant-reported outcome measures lack validated translations in other languages)

Exclusion

Unable or unwilling to follow coaching
Functional impairment resulting in inability to exercise
Any absolute contraindications to exercise:

What this trial measures

  • Change in Cardiorespiratory FitnessAt Baseline, Day -10, Day 90, and Day 365

    Change in cardiorespiratory fitness as measured by the difference in peak rate of oxygen consumption (VO2peak) in mL/(kg\*min) from baseline to the pre-hematopoietic stem cell transplant (HCT) timepoint; a higher number for VO2 peak indicates greater cardiorespiratory fitness.

  • Change in Physical Function (Six Minute Walk Test Distance)At Baseline, Day -10, Day 30, Day 90, Day 180, and Day 365

    The change in physical function as measured by the difference in six minute walk test distance in meters from baseline to the pre-hematopoietic stem cell transplantation (HCT) timepoint; a greater number of meters walked indicates a higher level of physical function.