Comparing Kidney Risk with Vancomycin Combinations

This study is for hospitalized adults with suspected or confirmed infections who are being treated with vancomycin. Researchers want to compare the risk of acute kidney injury (AKI) when vancomycin is given with either piperacillin-tazobactam or cefepime. Both combinations are commonly used, but there's a question about whether one might be safer for your kidneys. The study will measure a specific marker in your blood called Serum Cystatin C Concentration to see how your kidneys are doing. The goal is to understand which combination might be less likely to cause kidney problems. The study aims to enroll 750 participants, but its current status is unclear.

Study design
This is an interventional study comparing two standard antibiotic combinations. It aims to enroll 750 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your Serum Cystatin C Concentration will be measured 5 days after you join the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06954129

A Pragmatic Clinical Trial Comparing the Risk of Acute Kidney Injury During Treatment With Vancomycin and Piperacillin-Tazobactam vs. Vancomycin and Cefepime in Hospitalized Patients

Recruiting
PHASE4Ages 18+InterventionalTreatment
University of Pennsylvania
~750 participants
Updated 2026-02-13 on ClinicalTrials.gov
What's tested:VancomycinPiperacillin-tazobactamCefepime

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Serum Cystatin C Concentration
Measured over 5 days post enrollment
Acute Kidney Injury
1 sites across 1 states
Pennsylvania1

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  • Serum Cystatin C Concentration5 days post enrollment

    Change in serum cystatin c concentration through Day 5 after antibiotic initiation.