This study is exploring how a type of non-invasive brain stimulation called repetitive Transcranial Magnetic Stimulation (rTMS) affects motivation, memory, and brain function in older adults. This includes people with healthy aging, cognitive decline, and early stages of Alzheimer's disease (prodromal and preclinical Alzheimer's disease). All participants will receive both active rTMS and sham rTMS (a placebo version) to the left side of the brain that controls thinking. Researchers will measure changes in motivation, memory, and brain network connections to see if rTMS is helpful. You may be able to join if you are between 40 and 99 years old, a native English speaker, and willing to undergo testing and imaging.

Study design

This interventional study plans to enroll 80 participants. All participants will receive both active rTMS and sham rTMS.

What's involved

You will have a baseline visit, followed by 10 daily rTMS sessions (Monday-Friday), an evaluation visit, and then a 2-week break.

Compensation

Not stated in the trial record.

Follow-up

Changes in motivation, brain network connectivity, and memory will be measured at Baseline and post-treatment Day 11.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.