Reducing Dropout and Improving Outcomes From PTSD Therapy

This study is for Veterans with Post-Traumatic Stress Disorder (PTSD) who are interested in outpatient therapy. We are comparing different ways to help people who might be struggling with Cognitive Processing Therapy (CPT), a common treatment for PTSD. We want to see if using CPT skills to address challenges, or considering switching to Present Centered Therapy (PCT), works better to improve PTSD symptoms, depression, and how well people stay in treatment. We are also looking at different ways to identify when someone needs extra support during CPT. You would receive one of these therapy approaches. The main goal is to see how much your PTSD symptoms improve. We plan to enroll 280 participants, but the study's current status is unclear.

Study design
This is an interventional study planning to enroll 280 participants. It compares different behavioral interventions for PTSD.
What's involved
You would receive weekly 60-minute therapy sessions for an average of 4 months. You would also complete weekly self-report measures and agree not to receive other PTSD psychotherapy during the study.
Compensation
Not stated in the trial record.
Follow-up
Your PTSD severity will be measured at baseline and for six months after you complete treatment.

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NCT06957067

Reducing Dropout and Improving Outcomes From PTSD Therapy: When to Switch Therapies or Stay the Course

Recruiting
NAAges 18+InterventionalTreatment
United States Department of Defense
~280 participants
Updated 2025-11-14 on ClinicalTrials.gov
What's tested:CPT SkillsCognitive Processing TherapyPresent Centered TherapyShared Decision MakingMeasurement Based Care

At a glance

Recruiting sites
4 of 4 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
PTSD severity (via structured clinical interview)
Measured over Baseline, through six-months after treatment completion. Treatment completion takes an average of 4 months.
Post Traumatic Stress Disorder
4 sites across 4 states
Arizona1
Louisiana1
South Carolina1
Texas1
  • Laura Meis, PhD · PRINCIPAL_INVESTIGATOR · Women's Health Sciences Division of the National Center for PTSD; University of Minnesota
  • Princess Ackland, PhD · PRINCIPAL_INVESTIGATOR · University of Minnesota

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Veterans interested in outpatient VA psychotherapy for PTSD
Meets DSM-5 criteria for PTSD
Be able to provide informed consent
Be willing to be randomized
Agree to not receive non-study psychotherapy for PTSD during study treatment (case management, supportive therapy/group, and concurrent substance use treatment are allowable)

Exclusion

Severe cognitive impairment
Current suicidal or homicidal intent with a specific plan
Uncontrolled psychotic or manic symptoms
A psychiatric medication change in the past month
A severe SUD as diagnosed by the DSM-5
  • PTSD severity (via structured clinical interview)Baseline, through six-months after treatment completion. Treatment completion takes an average of 4 months.

    Measured using the Clinician-Administered PTSD Scale for the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (CAPS-5). This standardized interview is conducted by an evaluator blinded to study condition, via telehealth.