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Transcranial Magnetic Stimulation for Misophonia

This study is testing if Transcranial Magnetic Stimulation (TMS), a non-invasive brain stimulation technology, can help people with misophonia. TMS is already approved for depression and is being studied for other conditions like OCD and anxiety. You might be able to join if you are 18-55 years old, fluent in English, and experience irritation, anger, or fear due to specific sounds. The study aims to see if TMS can improve your tolerance to these sounds. Researchers will measure your unpleasantness ratings after each TMS session to see if the treatment is successful. The current recruitment status is unclear.

Study design
This study plans to enroll 60 participants. You will receive two types of Transcranial Magnetic Stimulation (TMS) sessions: one inhibitory and one excitatory.
What's involved
You will undergo two Transcranial Magnetic Stimulation (TMS) sessions, each lasting 25 minutes. Each session is 2 hours long, and they are 72 hours apart. You will also complete computerized tasks and have your brain activity (EEG), heart rate, and skin temperature recorded.
Compensation
Not stated in the trial record.
Follow-up
Your unpleasantness rating will be measured after each session, which are 72 hours apart.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06960083

Transcranial Magnetic Stimulation in Misophonia

Recruiting
NAAges 18–55InterventionalTreatment
Icahn School of Medicine at Mount Sinai
~60 participants
Updated 2026-07-21 on ClinicalTrials.gov
What's tested:Transcranial Magnetic Stimulation (TMS)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Unpleasantness Rating Scale
Measured over after each session, 72 hours apart (each session is 2 hours)

Conditions

Misophonia

Explore related trials

Misophonia

Where it's being run

1 sites across 1 states
New York1

Study leadership

  • Parul Jain, PhD · PRINCIPAL_INVESTIGATOR · Icahn School of Medicine at Mount Sinai

Who to contact

Shama Patel
[email protected]
347-670-4878
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Hypersensitive to presence of a specific sound, which may be accompanied by irritation, anger/outbursts, or fear.
Must be between the ages of 18 - 55.
Must be fluent in English since the study's instructions, surveys, and tasks will be in English.

Exclusion

Epilepsy or previous episode of convulsion or seizure.
Previous episode of fainting spell or syncope.
Head trauma.
Hearing problems.
Cochlear implant.
Metal in the brain, skull, or anywhere else in the body (e.g., splinters, fragments, clips, etc.).
Implanted neurostimulator (e.g., DBS, epidural/subdural, VNS).
Presence of cardiac pacemaker or intracardiac lines.
Presence of medication infusion device.
Use of pro-convulsant or epileptogenic medications.
Pregnancy. The risks associated with TMS exposure during gestation have not been studied extensively. We wish to safeguard the health of potential participants and their children.
Lactation. The risks associated with TMS during lactation and its effects on infant development have not been studied. We wish to safeguard the health of potential participants and their children.
Presence of Mania, Psychosis, Antisocial Personality Disorder, Borderline Personality Disorder, and Suicidal Ideation.

What this trial measures

  • Unpleasantness Rating Scaleafter each session, 72 hours apart (each session is 2 hours)

    Participants will be presented with a slider with extremes labelled as extremely unpleasant and extremely pleasant. Ratings will be provided for audio clips and visual cues. Full scale from 0-100, higher score indicates more unpleasantness