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NCT06960096

Cognitive Decline Following Deep Brain Stimulation: A DBS-fMRI Study

Recruiting
Not specifiedAges 18+Observational
Medical University of South Carolina
~55 participants
Updated 2025-10-14 on ClinicalTrials.gov
What's tested:DBS combined with fMRI

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in executive function performance
Measured over Baseline and approximately 1 year (10-14 months) following deep brain stimulation

Conditions

Deep Brain Stimulation
Parkinson Disease

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Parkinson Disease

NCT06960096

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Medical University of South Carolina

    Charleston, South Carolinastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Daniel Lench, PhD · PRINCIPAL_INVESTIGATOR · Medical University of South Carolina

Who to contact

Recruitment Coordinator
[email protected]
843-792-0235
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Subjects above 18 years of age
Individuals with a PD diagnosis as defined by the UK Brain Bank diagnostic criteria for Parkinson's disease (58) which have undergone a neurological and neuropsychological evaluation at MUSCs movement disorder center, and were selected to undergo 3T compatible unilateral or bilateral STN- DBS implants

Exclusion

Uncorrected visual or hearing impairments, as indicated by self-report
Individuals who are pregnant or expect to become pregnant during the course of the study
Individuals that have a history of neurological disease (other than PD) including previous stroke, major head trauma, and epilepsy or seizures.
Individuals with claustrophobia, or the inability to lie supine position in the MRI scanner
COPD with oxygen dependence
Non-MRI compatible metal implants (surgical clips or staples, cardiac pacemakers etc.)

What this trial measures

  • Change in executive function performanceBaseline and approximately 1 year (10-14 months) following deep brain stimulation

    Cognitive domains known to be affected by subthalamic deep brain stimulation (STN-DBS) will be evaluated using a standardized neuropsycholoical battery. A composite measure of tests within the executive function domain (task-switching, verbal fluency, and inhibitory control) will be assessed as the primary outcome measure for behavior.