XFIT: Exercise for Frailty in Lung Transplant Candidates

This study, called XFIT, is testing an 8-week exercise and behavior change program delivered through telehealth (video calls) for people who are candidates for a lung transplant and are experiencing frailty (weakness and reduced physical function). The program, called XFIT, aims to help you improve your physical activity from home. Researchers want to see if XFIT is safe, practical, and helps improve frailty and physical function. You could be eligible if you are between 18 and 65, speak English or Spanish, and meet certain physical criteria, including a specific score on a physical performance test (SPPB score ≤ 10). The main goal is to measure safety, looking at things like death, major heart problems, or multiple unplanned hospital stays within 8 weeks.

Study design
This study plans to enroll 70 participants who will be randomly assigned to either the XFIT program or enhanced standard care. It is an interventional study, meaning participants will receive a specific treatment.
What's involved
Participants will engage in 8 weekly sessions of the XFIT program, delivered via video conference, or receive enhanced standard of care. These sessions involve one-on-one exercise training and behavioral support.
Compensation
Not stated in the trial record.
Follow-up
The primary outcomes, such as death and major cardiovascular events, are measured at 8 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06960421

Exercise-based Frailty Intervention in Lung Transplantation (XFIT)

Not Yet Recruiting
NAAges 18–75Interventional
University of California, San Francisco
~70 participants
Updated 2025-06-03 on ClinicalTrials.gov
What's tested:XFIT

At a glance

Recruiting sites
0 of 4 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Death
Measured over 8 weeks
+2 more outcomes measured
Frailty
Lung Tranplant Candidate
4 sites across 4 states
California1
New York1
North Carolina1
Pennsylvania1
  • Jonathan Singer, MD, MS · PRINCIPAL_INVESTIGATOR · University of California, San Francisco

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Eligibility criteria

Inclusion

Age 18 - 65 years
Lung Transplant Candidates
Speaks English or Spanish
≤ 8LPM O2 on 6MWT
SPPB score ≤ 10
Age 18 - 75 years
Speaks English or Spanish
≤ 15LPM O2 on 6MWT
SPPB score ≤ 10

Exclusion

Lives Alone
BMI \< 18.0 kg/m2
Engaged in clinical pulmonary rehabilitation program
Severe pHTN (RHC mPAP ≥ 30 mmHg or TTE PASP ≥ 60mmHg or moderately/severely reduced RV systolic function on TTE
Deemed unsafe by site PI
Lives Alone
BMI \< 18.0 kg/m2
Engaged in clinical pulmonary rehabilitation program
Severely reduced RV systolic function on TTE
Deemed unsafe by site PI
  • Death8 weeks
  • Major cardiovascular event8 weeks
  • > 2 unplanned hospitalizations8 weeks