Two Versus One Week Breast Radiotherapy
This study is comparing two different radiation therapy (RT) schedules for early breast cancer to see which is more effective and has fewer side effects. One group will receive whole breast RT over one week (2600 cGy in five treatments). The other group will receive whole breast RT over two weeks (3200 cGy in ten treatments) with an extra focused dose (a "concomitant boost") to the area where the tumor was. The study will look at side effects after one month, as well as breast appearance and how well the treatments control the cancer over time. We are looking for women who have had a segmental mastectomy for pT1-2 breast cancer with clear margins, and who are clinically N0 or pN0-1 or Nx or sentinel node negative. The current status of this study is unclear.
- Study design
- This interventional study plans to enroll 400 women to compare two different radiation therapy schedules for breast cancer.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- The study will assess acute toxicity at 1 month and aims to evaluate local control at 2, 5, and 10 years.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Two Versus One Week Breast Radiotherapy (RT)
At a glance
Conditions
Where it's being run
3 sites across 1 statesStudy leadership
- Silvia C. Formenti, MD · PRINCIPAL_INVESTIGATOR · Weill Medical College of Cornell University
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Rate of RT-related acute toxicity1 month
The rate of RT-related acute toxicity is defined as cumulative acute toxicity events from the start of radiation treatment to 1 month follow up post RT. The toxicities will be graded by the research nurses assigned to the study according to Common Terminology Criteria for Adverse Events, version 5.0.