Mosaic Trial for Stem Cell Transplant Recipients

This study, called the Mosaic Trial, is looking at whether a special website (Mosaic) can help adult blood cancer patients who are having a stem cell transplant. You would be compared to a group using a different educational website. The goal is to see if the Mosaic website improves how you feel emotionally and psychologically after your transplant. To join, you need to be at least 18 years old, have a blood cancer, be scheduled for a stem cell transplant, and be able to use a website in English or Spanish. The study will measure improvements in general psychological distress from before your transplant to two months afterward. The study plans to enroll 356 people.

Study design
This is an interventional study where participants will be randomly assigned to use one of two study websites. It aims to enroll 356 participants.
What's involved
You would use one of two study websites and complete five assessments: one before your transplant and four after (at 2, 4, 6, and 8 months).
Compensation
Not stated in the trial record.
Follow-up
You will be followed for 8 months after your transplant, with assessments at 2, 4, 6, and 8 months.

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NCT06960993

Mosaic Trial for Stem Cell Transplant Recipients

Recruiting
NAAges 18+InterventionalSupportive care
Northwestern University
~356 participants
Updated 2026-08-03 on ClinicalTrials.gov
What's tested:Intervention websiteEnhanced Usual Care (Control) Website

At a glance

Recruiting sites
3 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Improvement in general psychological distress
Measured over Baseline to 2 months post-transplant
Hematologic Malignancy
Stem Cell Transplant
Bone Marrow Transplant
Leukemia
Lymphoma
Multiple Myeloma
Myelodysplastic Syndromes
3 sites across 3 states
District of Columbia1
Illinois1
New Jersey1

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Diagnosed with a hematologic cancer according to medical records
Scheduled for or preparing for scheduling of an allogeneic or autologous stem cell transplant at one of our study sites
Aged 18 or older (no upper limit)
English or Spanish Proficient
Interested in using a website to learn about stem cell transplant
Ability to understand and willingness to sign an informed consent document and comply with all study procedures

Exclusion

Currently participating in a behavioral intervention targeting distress, health-related quality of life, or symptoms
Undergoing the first in a planned tandem stem cell transplant
Unable to provide meaningful consent (severe cognitive impairment or language difficulties)
  • Improvement in general psychological distressBaseline to 2 months post-transplant

    Improvement in general psychological measured with the PROMIS-57 Profile v2.1 emotional distress composite score. Raw scores are calculated and converted to T scores ranging from 0 to 100, with higher scores indicating more severe distress.