Post-Operative Biomarker-Guided Precision Medicine For Cardiovascular Risk Reduction

This study is looking at whether a combination of two common medications, rivaroxaban (a blood thinner) and atorvastatin (a cholesterol-lowering drug), can help people who have experienced heart muscle injury (Myocardial Injury After Noncardiac Surgery, or MINS) after a major surgery. You might be able to join if you are 45 or older, recently had a major surgery, and had MINS. The main goal of this pilot study is to see how easy it is to enroll people and how well they take the medications, to help plan a larger study in the future. The study aims to enroll 50 participants. The current status of the study is unclear.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It is a pilot study designed to assess feasibility and optimize future study design, with a planned enrollment of 50 participants.
What's involved
If you participate, you would take rivaroxaban 2.5mg twice daily and atorvastatin 80mg daily for 6 months. The study will measure the percentage of pills taken at Month 6.
Compensation
Not stated in the trial record.
Follow-up
Your pill-taking will be measured at Month 6, which is the end of the treatment period.

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NCT06961630

Post-Operative Biomarker-Guided Precision Medicine For Cardiovascular Risk Reduction

Recruiting
EARLY_PHASE1Ages 45+InterventionalTreatment
NYU Langone Health
~50 participants
Updated 2026-04-06 on ClinicalTrials.gov
What's tested:RivaroxabanAtorvastatin

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percentage of pills taken at Month 6
Measured over Month 6
Myocardial Injury After Noncardiac Surgery
1 sites across 1 states
New York1
  • Nathaniel R. Smilowitz, MD, MS · PRINCIPAL_INVESTIGATOR · NYU Langone Health

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  • Percentage of pills taken at Month 6Month 6

    Treatment adherence will be assessed by pill count and patient self report.