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Cooling Strategies for Heart Failure During Heat Waves

This study is investigating ways to keep people with heart failure cool during hot weather. Researchers want to see if increasing skin wetness, either by spraying water or wearing a water-saturated T-shirt, can help lower body temperature and reduce stress on the heart during simulated heat waves. You might be able to join if you are 45 years or older and have heart failure, or if you are a healthy individual without significant medical problems. The study will measure changes in your core body temperature to see if these cooling methods are effective. The current status of this study is unclear.

Study design
This is an interventional study planning to enroll 88 participants. It compares three different cooling methods during simulated heat wave conditions.
What's involved
You will be exposed to a hot and dry environment for approximately 210 minutes in each of the three cooling conditions.
Compensation
Not stated in the trial record.
Follow-up
Your core body temperature will be measured before and after each simulated heat wave exposure, which lasts approximately 210 minutes.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06961929

IEEM-Heat and Heart Failure

Recruiting
NAAges 45+InterventionalPrevention
University of Texas Southwestern Medical Center
~88 participants
Updated 2026-05-26 on ClinicalTrials.gov
What's tested:Control TrialWater-saturated T-shirt trialSkin-Wetting Trial

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Core Body Temperature while wearing a water-saturated T-shirt
Measured over Prior to and after each simulated heat wave exposure (approximately 210 minutes.)
+5 more outcomes measured

Conditions

Heart Failure
Hyperthermia

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Heart Failure

NCT06961929

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Institute for Exercise and Environmental Medicine - Texas Health Presbyterian Hospital Dallas

    Dallas, Texasstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Craig Crandall, PhD
[email protected]
214-345-4623
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Participants must be free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram. Participants must be 45+ years.

Exclusion

Known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, lung disease, etc.; as well as serious abnormalities detected on routine screening. Current smokers, as well as individuals who regularly smoked within the past 12 months, will be excluded. Subjects who cannot be age and gender matched to an individual in the heart failure group will be excluded.
Patients who do not have confirmed diagnosis of NYHA class II or III heart failure will be excluded from the clinical group. Potential participants with cancer, diabetes, neurological disease, lung disease, and/or uncontrolled hypertension will be excluded. Potential participants with a left bundle branch block on ECG will be excluded. Patients on anticoagulant therapy will also be excluded. Current smokers, as well as individuals who regularly smoked within the past 12 months, will be excluded. Further exclusions will include severe valvular or congenital heart disease, acute myocarditis, NYHA Class IV heart failure, and/or manifest/provocable ischemic heart disease.

What this trial measures

  • Change in Core Body Temperature while wearing a water-saturated T-shirtPrior to and after each simulated heat wave exposure (approximately 210 minutes.)

    Core body temperature will be measured from gastrointestinal temperature via an ingestible telemetric pill or rectal temperature via telemetric pill suppository or rectal thermistor. Core body temperature will be measured at baseline as well as at the end of the hyperthermia simulation. The difference of those temperatures will reflect the change in core body temperature.

  • Change in Core Body Temperature in Skin-Wetting TrialPrior to and after each simulated heat wave exposure (approximately 210 minutes.)

    Core body temperature will be measured from gastrointestinal temperature via an ingestible telemetric pill or rectal temperature via telemetric pill suppository or rectal thermistor. Core body temperature will be measured at baseline as well as at the end of the hyperthermia simulation. The difference of those temperatures will reflect the change in core body temperature.

  • Change in Core Body Temperature in Control TrialPrior to and after each simulated heat wave exposure (approximately 210 minutes.)

    Core body temperature will be measured from gastrointestinal temperature via an ingestible telemetric pill or rectal temperature via telemetric pill suppository or rectal thermistor. Core body temperature will be measured at baseline as well as at the end of the hyperthermia simulation. The difference of those temperatures will reflect the change in core body temperature.

  • Change in Skin Temperature in while wearing a water-saturated T-shirtPrior to and after each simulated heat wave exposure (approximately 210 minutes.)

    Skin temperature will be measured from small temperature sensitive electrodes attached to the participant's skin. Skin temperature will be measured at baseline as well as at the end of the hyperthermia simulation. The difference of those temperatures will reflect the change in skin temperature.

  • Change in Skin Temperature in Skin-Wetting TrialPrior to and after each simulated heat wave exposure (approximately 210 minutes.)

    Skin temperature will be measured from small temperature sensitive electrodes attached to the participant's skin. Skin temperature will be measured at baseline as well as at the end of the hyperthermia simulation. The difference of those temperatures will reflect the change in skin temperature.

  • Change in Skin Temperature in Control TrialPrior to and after each simulated heat wave exposure (approximately 210 minutes.)

    Skin temperature will be measured from small temperature sensitive electrodes attached to the participant's skin. Skin temperature will be measured at baseline as well as at the end of the hyperthermia simulation. The difference of those temperatures will reflect the change in skin temperature.