Observational Study on Work:Rest Cycles and Temperature in Burn Survivors

This study is looking at how severe burn injuries affect your body's core temperature when you're doing work and rest cycles in a warm environment. Researchers want to compare people who have had serious burns (covering 20% or more of their body) with people who haven't had burns. You would spend time in a heated room (up to 40°C or 104°F) doing three cycles of exercise followed by rest. This will be done once in low humidity and once in high humidity. The main goal is to see how your core temperature changes during these cycles. To join, you need to be between 18 and 65 years old and generally healthy if you haven't had burns. The study is currently recruiting 70 participants.

Study design
This is an observational study comparing burn survivors to non-burned individuals. It plans to enroll 70 participants.
What's involved
You would undergo up to three work:rest cycles in a heated environmental chamber during two separate visits. Each cycle involves 30 minutes of exercise followed by up to 20 minutes of rest.
Compensation
Not stated in the trial record.
Follow-up
Core temperature will be measured from the start of exercise to the end of the last rest period, approximately at 0 and 170 minutes during each visit.

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NCT06966336

IEEM- Work:Rest Cycles in Burn Survivors- Humidity

Recruiting
Not specifiedAges 18–65Observational
University of Texas Southwestern Medical Center
~70 participants
Updated 2025-08-26 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in core temperature
Measured over From the start of exercise to the end of the last rest period. Approximately at 0 and 170 minutes.
Hyperthermia
Burn Injury
1 sites across 1 states
Texas1

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Eligibility criteria

Inclusion

Participants must be free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram. Participants must be between the ages of 18 and 65.

Exclusion

Known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, lung disease, etc.; as well as serious abnormalities detected on routine screening. Current smokers, as well as individuals who regularly smoked within the past 3 years will be excluded. Participants may also be excluded if body mass index is ≥ 31 kg/m2 will likewise be excluded. Participants must not have had a serious burn injury requiring more than 1 night stay in the hospital.
  • Change in core temperatureFrom the start of exercise to the end of the last rest period. Approximately at 0 and 170 minutes.

    Change in core body temperature will be measured either from a temperature sensor pill or from a rectal thermometer.