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Transcranial Magnetic Stimulation + Language Therapy for Subacute Aphasia

This study is testing if combining Transcranial Magnetic Stimulation (TMS) with modified Constraint Induced Language Therapy (mCILT) can help people with aphasia (language problems) after a stroke. Aphasia can make it hard to speak, understand, read, or write. TMS uses magnetic pulses to stimulate specific brain areas, and mCILT helps you practice using your impaired language skills. Researchers want to see if this combination improves overall speech better than mCILT alone. They are also looking for specific characteristics that might help predict who benefits most. You could be eligible if you are 18-85 years old, had a stroke in the left side of your brain 2-6 weeks ago that caused aphasia, and are right-handed and speak English. The study plans to enroll 63 participants.

Study design
This interventional study will compare real TMS to a sham (fake) TMS, with all 63 participants also receiving mCILT. The study aims to identify optimal and individualized stimulation intensity and site targeting.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your overall language function will be measured from the start of the study to 4 months after the interventions.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06968663

Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia

Recruiting
PHASE2Ages 18–85InterventionalTreatment
University of Pennsylvania
~63 participants
Updated 2026-06-18 on ClinicalTrials.gov
What's tested:Transcranial Magnetic Stimulation (TMS)Modified Constraint Induced Language Therapy (mCILT)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Overall language function
Measured over From Baseline to 4 months post-interventions

Conditions

Stroke
Aphasia
Aphasia Following Cerebral Infarction

Explore related trials

AphasiaStroke

NCT06968663

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Pennsylvania

    Philadelphia, Pennsylvaniastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • H. Branch Coslett, MD · PRINCIPAL_INVESTIGATOR · University of Pennsylvania

Who to contact

Leslie Vnenchak, MA, CCC-SLP
[email protected]
215-964-2502
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Left hemisphere stroke resulting in aphasia
The stroke must have occurred between 2 and 6 weeks prior to enrollment
Must be able to understand the nature of the study, and give informed consent
English proficiency
Right-handed

Exclusion

History of serious and/or ongoing issues with substance abuse
Previous head trauma with loss of consciousness for more than 5 minutes
History of major psychiatric illness
Dementia, or other neurological conditions
Epilepsy, or seizure after the stroke event
Pacemaker
Diagnosis of tinnitus
Pregnancy

What this trial measures

  • Overall language functionFrom Baseline to 4 months post-interventions

    Change in performance on the Western Aphasia Battery (WAB-AQ score). WAB AQ Score is out of 100, where a higher score means less language impairment.