Topical Estrogen for Transgender Men Undergoing Hysterectomy
This study is looking at whether applying a single dose of estradiol cream (a type of estrogen) inside the vagina right after a hysterectomy (removal of the uterus and cervix) can help transgender men. The goal is to see if this cream can reduce bleeding after surgery and improve feelings of gender dysphoria (discomfort or distress related to one's gender). You might be eligible if you are a transgender man, 18 or older, have been on testosterone for at least 6 months, and are planning to have a gender-affirming hysterectomy. The study will measure how much bleeding occurs in the first two weeks and how it affects your quality of life for up to six weeks after surgery. The current status of this study is unclear, and it plans to enroll 48 participants.
- Study design
- This is a double-blinded randomized pilot study, meaning neither you nor your doctors will know if you receive the estradiol cream or no treatment. About 48 participants will be randomly assigned to one of two groups.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- The study will evaluate bleeding for two weeks and quality of life for six weeks after your hysterectomy.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Topical Estrogen: Brief Intervention to Improve Postoperative Experience for Transgender Men Undergoing Hysterectomy
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
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What this trial measures
- Evaluate the efficacy of one-time topical estrogen application for reducing postoperative health system contacts for vaginal bleeding in the first two weeks post hysterectomy.2 weeks
The investigators hypothesize that administration of postoperative estrogen cream vaginally in the operating room will decrease the need for health system contact for bleeding in the initial postoperative period. Patients will be asked to complete a brief email survey on postoperative days: 1, 3, 7, \& 14 as well as at final postoperative visit \~42 days. This survey will target multiple things Outcome 1: Quantity of bleeding Determined by patient report: 1) small amount of spotting with wiping; 2) Staining pad, changing every 3-4 hours; 3) Bleeding like a light period; 4) Passing clots/heavy bleeding Additionally, chart review will be completed to assess for ED visits, office phone calls, MyChart Messages and any after-hours pages will be recorded.
- Examine the impact of topical estrogen application on postoperative healing as defined by number of days of bleeding and patient Quality of Life Measures.6 weeks
The investigators hypothesize that this intervention will demonstrate improved patient bleeding and dysphoria symptoms during the postoperative recovery period. The investigators will also measure mental health impact. Pre and postoperative Vanderbilt Mini Patient-Reported Outcome Measure - Gender (VMP-G)) scores will be obtained. This is a validated tool that assesses gender identity and gender affirming procedures as well as quality of life, self-concept, satisfaction, and gender dysphoria. (Hung 2023).