This study is comparing three medications used to prevent migraines: atogepant, propranolol, and topiramate. Researchers want to see if one of these medications works better or is easier to tolerate than the others for people with migraine. You might be able to join if you are an adult between 18 and 70 years old, have had migraines for at least a year, and experience at least four moderate to severe migraines per month. The study will measure success by seeing how many participants have a 50% or greater reduction in their moderate to severe headache days after 9-12 weeks on the assigned medication. The current recruitment status is unclear.

Study design

This is a randomized study comparing three different medications for migraine prevention, with a planned enrollment of 1335 participants.

What's involved

You would keep a daily headache diary for four weeks, and then for the first 16 weeks after randomization. You would also have research visits at baseline, four weeks later, and then at weeks 4, 8, 12, 24, and 48 after starting the study medication.

Compensation

Not stated in the trial record.

Follow-up

Participants are followed for 48 weeks after randomization, with the primary outcome measured at weeks 9-12 post-randomization.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.