Fezolinetant for Hot Flashes in Men with Prostate Cancer

This study is for men with prostate cancer who are experiencing hot flashes due to treatments that lower testosterone (Androgen Deprivation Therapy or ADT). Hot flashes can affect your quality of life, and researchers are looking for better ways to manage them. This study is testing a drug called fezolinetant, which is already approved for hot flashes in menopausal women. The goal is to see if fezolinetant can reduce your hot flashes. The study is looking for 32 men, aged 18 or older, who are currently receiving ADT. Success will be measured by how much your hot flash score is reduced after 28 days.

Study design
This is an interventional study with a planned enrollment of 32 men. Participants will receive fezolinetant at an FDA-approved dose.
What's involved
You would take fezolinetant by mouth once daily for 28 days. Your hot flash score will be measured at the end of this period.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured at 28 days.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06972875

Fezolinetant for Treating Hot Flashes in Men With Prostate Cancer

Recruiting
PHASE2Ages 18+InterventionalTreatment
University of Vermont
~32 participants
Updated 2026-02-05 on ClinicalTrials.gov
What's tested:Fezolinetant

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Reduction in Hot Flash Score
Measured over 28 day
Prostate CA
Androgen Deprivation Therapy
1 sites across 1 states
Vermont1

Opens a ready-to-send draft in your own email app — review before sending.

  • Reduction in Hot Flash Score28 day

    Assess the effect of fezolinetant 45 mg daily on the 7-day period participant-reported Hot Flash Score (HFS) at 4 weeks relative to baseline. The HFS sums the number of hot flashes multiplied by the intensity of each hot flash to estimate the overall hot flash burden during a 24 hour period, averaged over a 7 day period.