Non-Narcotic Pain Control After ACL Reconstruction

This study is looking at different ways to manage pain after surgery to repair a torn ACL (Anterior Cruciate Ligament, a major knee ligament). It compares two pain medications: ketorolac (a non-narcotic pain reliever) and oxycodone (a narcotic pain reliever). The goal is to see if ketorolac can reduce the number of narcotic pain pills people need after surgery, or even help them avoid narcotics completely. You might be able to join if you are between 15 and 55 years old, having your first ACL surgery using your own tissue, and can take oral medications. The study will measure how many narcotic doses are taken over the first 30 days.

Study design
This is a double-blind, randomized study with two groups, involving about 30 participants. Neither you nor your doctors will know which treatment you are receiving.
What's involved
You will need to take oral medication and participate in virtual follow-up calls at 1 and 2 weeks to count your pills.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome will be measured at 30 days after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06973785

Non-Narcotic Pain Control After ACL Reconstruction

Active, Not Recruiting
PHASE2Ages 15–55InterventionalTreatment
The Cleveland Clinic
~30 participants
Updated 2026-08-24 on ClinicalTrials.gov
What's tested:dispense of study drugKetorolac

At a glance

Recruiting sites
0 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Primary outcome
Measured over 30 days
ACL - Anterior Cruciate Ligament Rupture
ACL Injuries

NCT06973785

Where you'd take part

This study runs at 3 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Cleveland Clinic

    Strongsville, Ohiono site contact published

  • Cleveland Clinic Coral Springs

    Coral Springs, Floridano site contact published

  • Cleveland clinic sports medicine

    Garfield, Ohiono site contact published

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Kurt P Spindler, MD · PRINCIPAL_INVESTIGATOR · The Cleveland Clinic

This trial hasn't published a contact. View it on ClinicalTrials.gov

  • Primary outcome30 days

    How many narcotic pills were consumed