This study is looking at whether some patients with brain metastases (cancer that has spread to the brain) can avoid radiation therapy if their tumors respond well to other treatments like chemotherapy, targeted therapy, or immunotherapy. It will include 45 adults, mostly those with non-small cell lung cancer (NSCLC) and some with other solid tumors. You would receive your usual systemic therapy, and doctors would monitor your brain metastases with MRI scans. If your tumors are stable or shrinking, you might not need radiation. The main goal is to see how many NSCLC patients can avoid radiation for at least 6 months, especially depending on their PD-L1 status (a protein on cancer cells).

Study design

This is a pilot study with 45 participants, divided into two groups based on their cancer type. It is an interventional study, meaning participants will receive a specific treatment plan.

What's involved

You would undergo brain MRI scans every 3 months after starting systemic therapy. Radiation therapy would only be given if your disease progresses.

Compensation

Not stated in the trial record.

Follow-up

The primary outcome is measured at 6 months from your baseline brain MRI.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.