Magnesium's Effect on Neuromonitoring During Spine Surgery
This study is looking at how magnesium sulfate affects neuromonitoring during spine surgery. Neuromonitoring (Intraoperative neurophysiologic monitoring or IONM) helps doctors check your nerves during surgery to keep them safe. Researchers will give a single dose of magnesium sulfate through an IV over 10 minutes to adult patients having open thoracolumbar fusion surgery with planned neuromonitoring. The study will measure magnesium levels and how the body processes magnesium (pharmacokinetics) for about one year. You cannot join if you have significant heart or kidney disease, or liver problems. The current status of this study is unclear, and it plans to enroll 20 participants.
- Study design
- This is an interventional study planning to enroll 20 adult participants. It is not specified if it is randomized or blinded.
- What's involved
- You would receive a single intravenous dose of magnesium sulfate during surgery. Your magnesium levels and how your body processes magnesium will be measured for about one year.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed through study completion, an average of 1 year, to measure magnesium levels and pharmacokinetics.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Effect of Magnesium on Neuromonitoring
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Hemra Cil, MD · PRINCIPAL_INVESTIGATOR · University of California, San Francisco
Who to contact
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What this trial measures
- Serum Magnesium levelThrough study completion, an average of 1 year
Serum magnesium level will be measured by UCSF Lab.
- Magnesium- Pharmakokinetics Clearance (CL)Through study completion, an average of 1 year
Serum magnesium level will be measured by UCSF Lab. Then the investigators will run the Pharmakokinetics clearance (CL) data with the levels.
- Magnesium- Pharmacokinetics central volume of distribution (Vc)Through study completion, an average of 1 year
Serum magnesium level will be measured by UCSF Lab. Then the investigators will run the Pharmacokinetics Central volume of distribution (Vc) data with the levels.
- Magnesium- Pharmakokinetics (PK) intercompartmental clearance (Q)Through study completion, an average of 1 year
Serum magnesium level will be measured by UCSF Lab. Then the investigators will run the PK intercompartmental clearance (Q) data with the levels.
- Magnesium- Pharmakokinetics peripheral volume of distribution (Vp)Through study completion, an average of 1 year
Serum magnesium level will be measured by UCSF Lab. Then the investigators will run the PK peripheral volume of distribution (Vp) data with the levels.