This study is looking into two experimental drugs, Vonsetamig and Odronextamab, for adults with Lupus Nephritis (LN). LN is a serious kidney disease caused by lupus. The main goal is to understand how safe these drugs are and what side effects they might cause over a long period. This is an 'umbrella study,' meaning it includes several smaller studies testing different drugs for LN at the same time. You might be able to join if you are 18 to 60 years old, have been diagnosed with Systemic Lupus Erythematosus (SLE) and LN, and your disease has not responded well to other treatments or has come back. The study is also looking at how much drug is in the blood and if your body makes antibodies against the drugs.

Study design

This is an interventional study planning to enroll 90 participants. It is a dose escalation study, meaning different doses of the drugs will be tested.

What's involved

Not specified in the trial record.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed for treatment-emergent adverse events and their severity through week 76.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.