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Weight Loss Study for Prediabetes and Disabilities

This 16-week study is looking for people aged 18-75 with prediabetes (at risk for type 2 diabetes), obesity or overweight, and physical or mobility disabilities. It aims to find the most effective weight loss approach by testing two diets: a High Carbohydrate Diet and a Reduced Carbohydrate Diet, both combined with a group-based weight management program. At 4 weeks, your weight loss will be checked. If you lose 2.5% or more of your body weight, you'll continue with your assigned diet. The study will measure changes in your blood sugar (glucose) and body weight to see how well the treatments work. The study is currently unclear on its recruitment status.

Study design
This study is an interventional, sequential multiple assignment randomized trial (SMART) involving 30 participants.
What's involved
You would participate in a group-based weight management program and follow either a high or reduced carbohydrate diet for 16 weeks. Your body weight will be measured at baseline, week 4, and week 16, and glucose will be measured at baseline and week 16.
Compensation
Not stated in the trial record.
Follow-up
Participants are followed for 16 weeks, with final measurements taken at the end of this period.

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NCT06976307

Development of an Inclusive Adaptive Treatment Strategy for Weight Loss in People With Prediabetes Using a Sequential Multiple Assignment Randomized Trial

Active, Not Recruiting
NAAges 18–75InterventionalPrevention
University of Alabama at Birmingham
~30 participants
Updated 2026-07-08 on ClinicalTrials.gov
What's tested:High Carbohydrate DietReduced Carbohydrate Diet

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in glucose
Measured over Baseline & Week 16
+1 more outcome measured

Conditions

Disabilities
Obesity and Overweight
Prediabetes

Explore related trials

DisabilityObesityPrediabetes

Where it's being run

1 sites across 1 states
Alabama1

Study leadership

  • Christine Ferguson, PhD · PRINCIPAL_INVESTIGATOR · University of Alabama at Birmingham

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

18-75 years of age
BMI of 27 kg/m2 or greater for ambulatory individuals and 22 kg/m2 for individuals with spinal cord injury. Adjustments will be calculated for those with amputations and/or limb indifference
at risk for developing type 2 diabetes (prediabetes)
One or more physical or mobility disabilities
Stable medication type and dosage for 3 or more months for medications likely to affect body weight and/or appetite
Willing to complete requirements for participation

Exclusion

Pregnant, planning to become pregnant or breastfeeding
Currently taking medication(s) for weight loss
Medical history of Type 1 or 2 Diabetes, using exogenous insulin, using prescription or OTC weight loss medications within the past 3 months, current alcohol or drug abuse or dependence, smoker with unstable habits in the past 3 months, pacemaker or other life-threatening medical implant, eating disorder(s)

What this trial measures

  • Change in glucoseBaseline & Week 16

    Serum glucose will be measured in a fasted state.

  • Changes in body weightBaseline, Week4, and Week 16

    Measured on validated digital scale