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Decision Aid for Radioactive Iodine Treatment in Thyroid Cancer

This study is looking at whether a special website, called a decision aid, can help people with intermediate-risk thyroid cancer make informed choices about radioactive iodine (RAI) treatment. RAI is a treatment sometimes used to reduce the chance of cancer coming back. The study wants to see if this decision aid helps you understand the benefits and risks of RAI, and if it helps you make a choice that fits your personal values. You would be randomly assigned to either use this decision aid website or receive information from the American Cancer Society website. The study aims to enroll 408 participants who have been recently diagnosed with intermediate-risk differentiated thyroid cancer (DTC) and are deciding about RAI treatment.

Study design
This interventional study plans to enroll 408 participants and will randomly assign them to one of two groups: one receiving a decision aid website and the other receiving usual care information.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, informed choice about RAI treatment, will be measured at 4 weeks.

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NCT06980103

Use of a Decision Aid to Resolve Uncertainty About Radioactive Iodine Treatment in Patients With Intermediate Risk Thyroid Cancer

Recruiting
NAAges 18+Interventional
Georgetown University
~408 participants
Updated 2026-01-08 on ClinicalTrials.gov
What's tested:Decision AidUsual Care

At a glance

Recruiting sites
3 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Informed choice about RAI treatment
Measured over 4 weeks

Conditions

Thyroid Cancer

Explore related trials

Thyroid Gland Carcinoma

Where it's being run

3 sites across 2 states
District of Columbia2
Virginia1

Who to contact

Lourdes M Inbar-Albo, MD,MSc. Project Director
[email protected]
202-687-3628
Email the study team

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Eligibility criteria

Inclusion

Patients aged 18 and older
Patients diagnosed with intermediate risk DTC \< 6 months ago and who are making a decision about RAI treatment
Ability to understand the information conveyed in the informed consent form, pose questions and process answers (e.g., no cognitive impairment per direct consultation with the patient's physician), and, finally, provided informed consent to participate.
Participants willingness to be contacted and remain available to complete study activities throughout the duration of the study.

Exclusion

Diagnosis of low risk or high risk DTC
Prior history of RAI
Clinical contraindications that prevent consideration of RAI (e.g., pregnancy, lactation, neutropenia if considering high dose of RAI)

What this trial measures

  • Informed choice about RAI treatment4 weeks

    The primary outcome is informed choice measured with the Multi-Dimensional Measure of Informed Choice (MMIC). The scores for informed choice include two components: knowledge categorized as high/low based on the mid-point in the range of scores on the knowledge measure (minimum score of 0 and maximum score of 10; higher scores indicate greater knowledge) and values (attitudes) that are categorized as positive or negative based on the mid-point on the attitude items (minimum score of 4; maximum score of 28; higher scores more greater alignment of the RAI treatment decision with personal values. Informed choice is characterized as informed or uninformed. An informed choice means a decision based on high knowledge and values (attitudes) that align with the patient's preferences and final treatment decision. An uninformed choice occurs when a patient has low knowledge or makes a decision that doesn't match their personal values and attitudes.