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Evaluating the pNANO Assessment for Pediatric Brain and Spine Tumors

This study is evaluating a new way to assess children with brain or spinal cord tumors called the pNANO Assessment. This assessment looks at things like how you walk (gait), strength, balance (cerebellar function), vision, and facial strength. The goal is to see if different doctors get similar results when using the pNANO Assessment, which could help make tumor response assessments more consistent. You can join if you are between 1 and 17 years old and have a brain or spine tumor. The study aims to enroll 252 participants. Success will be measured by how consistent the pNANO scores are between different clinicians at two visits, up to 6 months apart. The current recruitment status is unclear.

Study design
This is an observational study where 252 participants will have their neurologic examinations performed by 2-3 different clinicians. The clinicians will not discuss their findings with each other.
What's involved
You will have the pNANO Assessment performed by 2-3 different clinicians during two routine clinic visits. The second visit will be between 1 and 6 months after the first.
Compensation
Not stated in the trial record.
Follow-up
You will be assessed at a second clinic visit, between 1 and 6 months after the initial assessment.

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NCT06981156

Evaluation of the Neurologic Assessment in Pediatric Neuro-Oncology (pNANO)

Recruiting
Not specifiedAges 1–17Observational
University of Wisconsin, Madison
~252 participants
Updated 2026-07-21 on ClinicalTrials.gov
What's tested:pNANO Assessment

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Inter-observer Variability in pNANO Scores: Difference in Mean Cumulative Scores
Measured over Visit 1 (baseline), Visit 2 (up to 6 months)

Conditions

Pediatric Brain Tumor
Pediatric Spine Tumor

Explore related trials

Brain NeoplasmSpine tumor

Where it's being run

1 sites across 1 states
Wisconsin1

Study leadership

  • Austin Stuckert, MD · PRINCIPAL_INVESTIGATOR · UW School of Medicine and Public Health

Who to contact

Cancer Connect
[email protected]
800-622-8922
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

greater than or equal to 1 year old
must be seen in the pediatric clinic
Radiographic or histologic confirmation of a brain or spine tumor at the time of initial diagnosis
Patient or parent/guardian must be able to understand the consent and be willing to sign a written informed consent document according to institutional guidelines.

Exclusion

none specified

What this trial measures

  • Inter-observer Variability in pNANO Scores: Difference in Mean Cumulative ScoresVisit 1 (baseline), Visit 2 (up to 6 months)

    The Pediatric Neurologic Assessment in Neuro-Oncology (pNANO) is scored in multiple domains: - strength, level of consciousness, and gait domains (each individually scored 0-3) * facial strength, cerebellar function, visual fields, extraocular movements, dysphagia, and dysarthria domains (each individually scored 0-2) * visual acuity domain scored from 0-1 If summed, cumulative scores range from 0 (normal) to 22 (inability to function in each relevant domain) Investigators will explore variability across all domains.