Obicetrapib for Antioxidant Levels in Healthy Volunteers

This study is looking into whether Obicetrapib, a drug, can change the levels of antioxidants in your blood and in the tissues of your eyes. Researchers want to see if Obicetrapib helps your body absorb antioxidants better. You would either receive Obicetrapib or a placebo (a substance with no active drug) daily for four months. The study is open to healthy volunteers aged 18 to 75 who have good vision. Success for this study means seeing a change in antioxidant levels in your HDL (high-density lipoprotein, a type of cholesterol) after 16 weeks. The current status of this study is unclear, and it aims to enroll 100 participants.

Study design
This is an interventional study comparing Obicetrapib to a placebo, with a planned enrollment of 100 healthy volunteers.
What's involved
You would take Obicetrapib or a placebo daily for 4 months, visit the clinic every 8 weeks for checkups, and have blood and eye tests to measure antioxidant levels.
Compensation
Not stated in the trial record.
Follow-up
Antioxidant levels in HDL will be measured at 16 weeks, indicating the duration of the primary follow-up.

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NCT06982508

Evaluation of Obicetrapib on Antioxidant Levels in Plasma and HDL Particles of Healthy Volunteers

Recruiting
PHASE2Ages 18–75InterventionalBasic science
NewAmsterdam Pharma
~100 participants
Updated 2025-10-20 on ClinicalTrials.gov
What's tested:Obicetrapib 10mgPlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Sum of Percent Change of Antioxidant Levels within HDL
Measured over 16 Weeks
Antioxidant Absorption
1 sites across 1 states
Florida1

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Visual acuity \> 20/60 in both eyes with or without corrective lenses

Exclusion

Type 2 diabetes
Active liver disease
Any clinically significant macular pathology
  • Sum of Percent Change of Antioxidant Levels within HDL16 Weeks

    The primary efficacy endpoint is the effect of obicetrapib on the sum of the percent changes in lutein, zeaxanthin, and α-tocopherol levels within HDL particles from baseline to visit 4 (week 16) compared to placebo.