This study is looking into a new treatment called Prism for people with Major Depressive Disorder (MDD) who also experience anhedonia (a loss of pleasure or interest in activities). Prism is a software device that uses neurofeedback training in a clinic. The study aims to see if Prism training can help reduce symptoms of anhedonia. You might be able to join if you are between 22 and 75 years old, have MDD with anhedonia, and can speak and understand English. Researchers will measure changes in your depression symptoms using a tool called HDRS-21 to see if the treatment is successful. The study plans to enroll 170 participants.

Study design

This interventional study plans to enroll 170 participants. It will compare changes in depression scores between an active treatment group and a sham (inactive) group.

What's involved

You would complete 20 Prism training sessions over 10 weeks, twice a week. There will also be two booster sessions and follow-up visits, including MRI and EEG measurements.

Compensation

Not stated in the trial record.

Follow-up

Your progress will be followed for 12 weeks after the main training, with a final assessment at week 24.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.