Adaptive Radiation for Locally Advanced Pancreatic Cancer

This study is looking at a new way to give radiation called Adaptive Radiation Therapy (ART) for people with locally advanced pancreatic cancer that cannot be removed by surgery. ART creates a personalized radiation plan for each treatment session, which means the plan can change daily to target the tumor more precisely and protect healthy tissue nearby. The main goal is to see if ART can reduce side effects like stomach and bowel problems. To join, you must have pancreatic cancer that is locally advanced and unresectable. The study plans to enroll 16 participants, but its current status is unclear.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 16 participants.
What's involved
You would have CT scans to plan radiation, potentially have 1-3 small markers placed near the tumor, undergo a tumor biopsy, and receive 5 radiation treatments every other day over a two-week period.
Compensation
Not stated in the trial record.
Follow-up
Researchers will monitor for side effects like gastrointestinal toxicity for up to 3 months after the end of radiation treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06984562

Adaptive Radiation for Locally Advanced Unresectable Pancreatic Cancer

Recruiting
NAAges 18+InterventionalTreatment
Fox Chase Cancer Center
~16 participants
Updated 2025-10-29 on ClinicalTrials.gov
What's tested:Adaptive Radiation Therapy

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
The rate of acute and late grade ≥3 gastrointestinal toxicity occurring within 3 months of treatment possibly, probably or definitely related to radiation.
Measured over From start of radiation to 3 months after the end of radiation treatment
Locally Advanced Pancreatic Ductal Adenocarcinoma (PDA)

NCT06984562

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvaniastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Joshua Meyer, MD · PRINCIPAL_INVESTIGATOR · Fox Chase Cancer Center

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Eligibility criteria

Inclusion

ANC ≥ 1,500/µl and PLT ≥ 100,000/µl
Bilirubin less than 1.5 ULN
AST and ALT \< 3X ULN
Serum Creatinine \<1.5X ULN 6. Women of childbearing potential must not be pregnant (negative pregnancy test within 72 hours prior to registration). Postmenopausal woman must have been amenorrheal and non-lactating for at least 12 months to be considered of non-childbearing potential. Men and women of childbearing potential must be willing to exercise an effective form of birth control (abstinence/contraception) while on study and for at least 6 months after therapy is completed. 7. Age ≥ 18 years 8. Participants must sign a written informed consent and HIPAA consent prior to performance of study-specific procedures or assessments and must be willing to comply with treatment, tissue sample collections, and follow-up.
  • The rate of acute and late grade ≥3 gastrointestinal toxicity occurring within 3 months of treatment possibly, probably or definitely related to radiation.From start of radiation to 3 months after the end of radiation treatment