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Evaluating Ventilation in Muco-Obstructive Lung Disease

This study is looking at how mucus plugs affect breathing in people with lung conditions like severe asthma, COPD (chronic obstructive pulmonary disease), non-CF bronchiectasis (a lung condition not caused by cystic fibrosis), and cystic fibrosis (CF). Researchers will use a special MRI scan with Hyperpolarized 129 Xenon gas to see how well air moves in parts of the lungs that have mucus plugs. The goal is to understand the impact of these mucus plugs on your lung function. You might be able to join if you are 18-65 years old and have one of these lung conditions. The study aims to understand how ventilation defects (areas where air doesn't move well) relate to mucus-blocked regions. The current recruitment status is unclear.

Study design
This is an observational study, meaning researchers will observe participants without assigning treatments. It plans to enroll 8 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Ventilation defects will be measured at baseline (at the start of the study).

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NCT06985225

Evaluation of Ventilation Defects Downstream of Mucus Plugs in Patients With Muco-Obstructive Lung Disease

Recruiting
Not specifiedAges 18–65Observational
University of Kansas Medical Center
~8 participants
Updated 2026-07-01 on ClinicalTrials.gov
What's tested:Hyperpolarized 129 Xenon

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Ventilation Defect in Mucus blocked Regions
Measured over Baseline

Conditions

Severe Asthma
COPD
Non-CF Bronchiectasis
Cystic Fibrosis (CF)

Explore related trials

Chronic Obstructive Pulmonary DiseaseCystic FibrosisNon-Cystic Fibrosis BronchiectasisSevere asthma

Where it's being run

1 sites across 1 states
Kansas1

Who to contact

Cristal Monge
[email protected]
(913) 945-9399
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Adequate completion of informed consent process with written documentation
Patients 18 - 65 years old
• Physician diagnosis of muco-obstructive pulmonary disease, including cystic fibrosis, severe asthma, chronic obstructive pulmonary disease, or non-cystic fibrosis bronchiectasis for \> 1 year
Able to perform reproducible spirometry according to ATS criteria based on clinical PFTs.

Exclusion

Respiratory tract infection within the 4 weeks prior to Visit 1
Body mass index (BMI) \> 30 at Visit 1
One-time doses such as intra-articular injections require a 4-week washout prior to Visit 1
ER visit related to pulmonary condition within the previous 4 weeks of Visit 1
Significant concomitant medical illness, including (but not limited to) heart disease, cancer, uncontrolled diabetes, other chronic lung diseases (determined by the Investigator.)
Resting O2 saturation \<90% with maximum supplemental O2 delivered by nasal canula
Positive urine pregnancy test
Participation in an intervention study (including bronchoscopy) or use of investigative drugs within the past 30 days or plans to enroll in such a trial during the study
Unable or unlikely to complete study assessments in the opinion of the Investigator
Study intervention poses undue risk to patient in the opinion of the Investigator
Conditions that will prohibit MRI scanning determined by the MRI safety screening.

What this trial measures

  • Ventilation Defect in Mucus blocked RegionsBaseline

    The primary endpoint of this study is the ventilation defect percent (VDP; measured by Xe-MRI) in regions of the lungs that are downstream of mucus plugs (identified on CT imaging).