Oral Chemotherapy Adherence Intervention for Cancer Patients

This study is testing a new program called the Multilevel Adherence Intervention to help people with cancer take their oral anticancer agents (chemotherapy pills) correctly. The program involves personalized counseling sessions with a clinical pharmacist. These pharmacists will help you understand how to take your medication, manage side effects, and plan your treatment. The study aims to see how well this program works and how easy it is to use. We are looking for 160 adults, aged 21 or older, who have either solid tumors or blood cancers (hematologic malignancies) and have been taking oral anticancer agents for at least six months. The study will measure how well people stick to their medication schedule and how acceptable and appropriate the program is.

Study design
This study will include 160 participants and will compare two groups: one group before the program was implemented and another group who has been in the program for at least six months.
What's involved
You will have individualized counseling sessions with a clinical pharmacist, who will review your medication and provide ongoing support. Your interactions with the pharmacist will vary based on your monitoring risk category.
Compensation
Not stated in the trial record.
Follow-up
The study will measure acceptability and appropriateness after 6 months.

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NCT06989489

Implementation of an Oral Chemotherapy Adherence Intervention

Recruiting
NAAges 21+InterventionalSupportive care
UNC Lineberger Comprehensive Cancer Center
~160 participants
Updated 2026-07-08 on ClinicalTrials.gov
What's tested:Multilevel Adherence Intervention

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Oral Medication Adherence
Measured over Baseline and week 4
+3 more outcomes measured
Solid Tumor
Hematologic Malignancy

NCT06989489

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • UNC Chapel Hill

    Chapel Hill, North Carolinastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Benyam Muluneh, PharmD · PRINCIPAL_INVESTIGATOR · UNC Lineberger Comprehensive Cancer Center

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Eligibility criteria

Inclusion

Adult (age ≥21 years-old) patients
Diagnosed with a solid or hematologic malignancy
Monotherapy on oral anticancer agent on treatment for at least 6 months

Exclusion

Patients on time-limited or intermittent therapy (non-continuous)
Patients on comfort (end-of-life) care
Patients enrolled on hospice
  • Oral Medication AdherenceBaseline and week 4

    Patient's medication adherence of their oral anticancer regiment will be quantified using the PROMIS- medication adherence Likert-type questionnaire, from strongly disagree to strongly agree. Score will change from 1 to 5, with a maximum of 50 and minimum of 10. A higher score reflects better adherence. These answers will help the investigators see if the program was effective in helping the patient's medication adherence.

  • AcceptabilityAfter 6 months

    A study specific survey will be used to measure acceptability. Survey will have Likert-type questions, 1-5 strongly disagree to strongly agree, a higher score reflects better acceptance. Clinicians and administrators will answer the survey to capture their acceptability of the various aspects of the intervention.

  • AppropriatenessAfter 6 months

    A study specific survey will be used to measure appropriateness. Survey will have Likert-type questions, 1-5 strongly disagree to strongly agree, a higher score reflects better appropriateness. the survey will capture how well the clinicians and administrators graded the various aspects of the intervention.

  • Everyday useAfter 6 months

    A study specific survey will be used to measure how applicable for everyday use. Survey will have Likert-type questions, 1-5 strongly disagree to strongly agree, a higher score reflects better everyday use. The survey will capture how easy the intervention is for clinicians and administrators.