Study on Troriluzole and Methamphetamine Use Disorder

This study is looking at how a drug called troriluzole might affect the impact of methamphetamine in people with methamphetamine use disorder. Researchers will give participants either a placebo (an inactive substance) or methamphetamine intravenously (into a vein) during experimental sessions. The main goal is to see how methamphetamine's reinforcing effects (how much someone wants to use it) change over about one month while participants are staying in the hospital. You might be able to join if you are 18-55 years old, speak English, and have recently used methamphetamine. The study is currently unclear on its recruitment status.

Study design
This is an interventional human laboratory study planning to enroll 40 participants. It will involve giving participants either placebo or methamphetamine.
What's involved
Participants will have methamphetamine's reinforcing effects measured 9 times over approximately a 1-month inpatient admission.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured over approximately 1 month of inpatient admission.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06989853

Methamphetamine and Troriluzole

Recruiting
EARLY_PHASE1Ages 18–55InterventionalBasic science
William Stoops
~40 participants
Updated 2026-06-08 on ClinicalTrials.gov
What's tested:PlaceboMethamphetamine

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Reinforcing Effects of Methamphetamine
Measured over 9 times over approximately 1 month inpatient admission
Methamphetamine Use Disorder
1 sites across 1 states
Kentucky1

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  • Reinforcing Effects of Methamphetamine9 times over approximately 1 month inpatient admission

    Number of Times Subjects Hypothetically Choose Methamphetamine Over Money between $0 and $140