Tirzepatide for Alcohol Use Disorder and Overweight/Obesity

This study is looking at how a medication called tirzepatide might help adults who have alcohol use disorder (AUD) and are also overweight or have obesity. You could be eligible if you are between 21 and 65 years old, meet specific criteria for AUD, and have a Body Mass Index (BMI) of 27 or higher. Participants will receive weekly injections of either tirzepatide (2.5mg or 5.0mg) or a placebo (an inactive substance). The main goal is to see if tirzepatide reduces the number of heavy drinking days over the last four weeks of treatment. The study aims to enroll 42 participants, but its current recruitment status is unclear.

Study design
This is a Phase 2 randomized controlled trial, meaning participants will be randomly assigned to receive either tirzepatide or a placebo. The study plans to enroll 42 participants.
What's involved
You would need to attend weekly medication visits and complete all study procedures. The primary endpoint is measured at the last 4 weeks of treatment (Weeks 5-8).
Compensation
Not stated in the trial record.
Follow-up
The primary outcome is measured at the last 4 weeks of treatment (Weeks 5-8), but further follow-up is not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06994338

Tirzepatide for Alcohol Use Disorder

Recruiting
PHASE2Ages 21–65InterventionalTreatment
University of Southern California
~42 participants
Updated 2025-10-14 on ClinicalTrials.gov
What's tested:TirzepatidePlacebo injections

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of heavy drinking days
Measured over Last 4 weeks of treatment (Weeks 5-8)
Alcohol Use Disorder
Obesity and Overweight
Alcohol
1 sites across 1 states
California1

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  • Number of heavy drinking daysLast 4 weeks of treatment (Weeks 5-8)

    Number of heavy drinking days (NHDD) during the last four weeks of treatment (treatment Weeks 5-8), as measured by the Timeline Followback interview. NHDD is defined as the total number of days on which participants consumed 5 or more drinks (for men) or 4 or more drinks (for women). The analysis of NHDD will control for baseline NHDD (defined as NHDD in the four weeks preceding treatment).