Improving Executive Control in Cognitively Healthy Older Adults: the MUltitasking STrategy (MUST) Study

This study is looking for healthy adults aged 60-75 to see if playing a complex online game can improve their "executive control" (the mental skills needed for planning, problem-solving, and multitasking). You would either learn to play a web-based cognitive training game with specific guidance, play the same game without guidance, or be in a group that doesn't play the game. Researchers will measure changes in your game scores and other cognitive tests to see if the training helps. This research aims to find ways to reduce age-related cognitive decline and the risk of Alzheimer's disease.

Study design
This interventional study plans to enroll 130 participants aged 60-75. Participants will be randomly assigned to one of three groups: web-based cognitive training with strategy, web-based cognitive training without strategy, or no intervention.
What's involved
You would attend 2 in-person assessments, have a blood test, and participate in 10 one-hour online training sessions 2-3 times a week over one month. You would also complete an online follow-up assessment.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for cognitive assessments at baseline, immediately after the intervention (weeks 10-12), and at a 3-month follow-up (week 24).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06995638

Improving Executive Control in Cognitively Healthy Older Adults: the MUltitasking STrategy (MUST) Study

Recruiting
NAAges 60–75InterventionalTreatment
Rutgers, The State University of New Jersey
~130 participants
Updated 2025-12-15 on ClinicalTrials.gov
What's tested:Web-based Cognitive Training (with strategy)Web-based Cognitive Training (without strategy)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Changes in the Breakfast Game scores
Measured over Training session 1, week 1; training 10, approximately 4 weeks.
+1 more outcome measured
Healthy Aging
Alzheimer's Disease (AD)
1 sites across 1 states
New Jersey1
  • Sharon Sanz Simon Assistant Professor, Ph.D. · PRINCIPAL_INVESTIGATOR · Rutgers University
Thamiris Golçalves Clinical Research Coordinator, MS
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Eligibility criteria

Inclusion

Age 60-75
Adequate English proficiency
Willingness to adhere to training protocol:
Attend 2 in-person assessments
Attend a blood test
Attend online intervention sessions and online follow-up assessment

Exclusion

Low test scores (below 26 on the Montreal Cognitive Assessment)
Known history of cognitive impairment, dementia, stroke, seizure disorder, or other neuropsychiatric condition judged to impact cognitive performance.
Taking medications known to influence cognitive performance.
Sensory (e.g. visual, auditory) or physical (e.g. severe arthritic, orthopedic, neurologic) impairment incompatible with use of a standard computer workstation.
Enrolled in a concurrent study that could affect the outcome of this study.
  • Changes in the Breakfast Game scoresTraining session 1, week 1; training 10, approximately 4 weeks.

    Change in the total game performance based on specific scores (number of tables and cooking scores). Higher scores represent better game outcomes.

  • Transfer to complex executive/attention control measure (Proximal outcome).At baseline (week 1); post-intervention (weeks 10th to 12th); and at 3-month follow-up (week 24th)

    Alphanumeric Task score.