Arm Basis Training for Post-Stroke Arm Rehabilitation
This study is looking into how a specific type of therapy, called Arm Basis Training, can help people regain arm movement after a stroke. Many people have difficulty moving their arm after a stroke, and while therapy is common, we don't fully understand how it changes the brain. This research aims to learn more about the brain pathways involved in arm movement and how they change with this rehabilitation. We hope this knowledge will lead to better treatments for stroke-related disability. You might be able to join if you had your first stroke 3-6 months ago, have some arm weakness, and can participate in a 6-week intensive arm therapy program in English. We will measure changes in your arm movement and brain pathways to see if the therapy is successful. The current recruitment status is unclear.
- Study design
- This is an interventional study planning to enroll 50 participants. It is not specified if participants will be randomly assigned to different groups.
- What's involved
- You would participate in a 6-week intensive upper extremity intervention. Measurements of your arm movement and brain activity would be taken before and after this 6-week period.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for changes measured at pre- and post- 6 weeks of therapy.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Substrates for Post-Stroke Arm Rehabilitation
At a glance
Conditions
NCT06998485
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Laboratory for Translational Neurorecovery, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital
Boston, Massachusettsstudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- David J Lin, MD · PRINCIPAL_INVESTIGATOR · Massachusetts General Hospital
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
Want this trial checked against your situation?
Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.
Inclusion
Exclusion
What this trial measures
- Change in Kinematic Measure of Upper Extremity Motor ControlPre- and post- 6 weeks of therapy
Kinematic measures of Upper Extremity Motor Control include joint individuation index (a measure of how well joints can move independently of other joints) and shoulder-elbow coordination (a measure of how normal a point-to-point planar reaching movement is)
- Change in Corticospinal Tract Axon Density on MRIPre- and post- 6 weeks of therapy
High-resolution diffusion MR neuroimaging will be performed, from which corticospinal tract axon density will be calculated
- Change in Corticospinal Tract NeurophysiologyPre- and post- six weeks of therapy
The primary neurophysiologic measure of interest will be MEP presence or absence at proximal upper extremity muscles. If MEP positive, secondary measures of corticospinal excitability will be the MEP recruitment curve slope as well as MEP amplitude (at 100% MSO).