This study is for adults aged 18-89 who have chronic throat symptoms like cough, throat clearing, or hoarseness (dysphonia) and are being evaluated for laryngopharyngeal reflux (LPR). Researchers want to see if a personalized approach, called Laryngeal Recalibration Therapy (LRT) combined with GERD Lifestyle Recommendations and tailored acid suppression, works better than the usual treatment with Omeprazole 40 MG (a proton pump inhibitor, or PPI). The goal is to find out if more people get relief from their symptoms with the personalized approach. You would need to be off acid suppression for at least two weeks before joining.

Study design

This interventional study plans to enroll 160 participants. Researchers will compare a personalized treatment strategy to a usual care strategy.

What's involved

You will undergo screening, including an upper endoscopy and reflux monitoring. After this, you will have an intervention visit about one week later.

Compensation

Not stated in the trial record.

Follow-up

Your symptom response will be measured at 5 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.