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NCT07003802

Neural Control and Mechanosensation in Spine Muscle

Enrolling by Invitation
NAAges 18–60InterventionalBasic science
University of California, San Diego
~152 participants
Updated 2026-05-01 on ClinicalTrials.gov
What's tested:Resistance exercise

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
RMS amplitude of paraspinal muscle EMG
Measured over Baseline
+3 more outcomes measured

Conditions

Low Back Pain and Core Muscle
Disc Herniation

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NCT07003802

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • UC San Diego

    La Jolla, Californiano site contact published

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Bahar Shahidi, PT, PhD · PRINCIPAL_INVESTIGATOR · UC San Diego

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

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Eligibility criteria

Inclusion

Surgical group:
Individuals diagnosed with chronic disc injury (symptoms \> 3 months),
Individuals planning to undergo a spinal surgery to address the diagnosis of chronic disc injury
Individuals diagnosed with chronic disc injury (symptoms \>3 months),
Individuals initiating an exercise-based physical therapy program to address the diagnosis of chronic disc injury
Individuals with no history of chronic back pain (interfering pain lasting \>3 months) within the past 3 years,
no significant spinal pathology beyond normal age-related degenerative changes

Exclusion

Surgery/Physical therapy groups-History of lumbar spine surgery
Diabetes
Neuromuscular diseases
Epilepsy or other seizure disorder -Healthy control group -
History of lumbar spine surgery
History of interfering pain lasting \>3 months
Diabetes
Neuromuscular diseases
Epilepsy or other seizure disorder

What this trial measures

  • RMS amplitude of paraspinal muscle EMGBaseline

    Average RMS EMG amplitude of the lumbar multifidus over the duration of the acute exercise bout.

  • IVIM responsivenessBaseline

    Response classification from IVIM MRI imaging as an increase in IVIM Diffusion (D) of at least 0.055 x 10-3 mm2/s and a pseudodiffusion (D\*) increase of at least 6.94 x 10-3 mm2/s in response to the acute exercise stimulus

  • Cortical excitabilityBaseline

    Transcranial Magnetic Stimulation based motor threshold of activation of the lumbar multifidus muscle

  • pAMPKTime of surgery/biopsy

    Mechanically-induced phosphorylation of p38 MAPK-Thr180/Tyr182 (p-p38T180/Y182) from intraoperative multifidus biopsies or biopsy needle