Comparing Breathing Support Methods During Weaning from Ventilator

This study is for adults in the intensive care unit (ICU) who have been on a breathing machine (mechanical ventilation) for at least 24 hours. It compares two ways to help you breathe during a "spontaneous breathing trial" (SBT), which is a test to see if you can breathe on your own. The two methods are called Pressure Support Ventilation (PSV) and Automatic Tube Compensation (ATC). Researchers want to see which method leads to more successful removal of the breathing tube (extubation). To join, you must be 18 or older and meet certain screening criteria. The main goals are to see if you need to be re-intubated or if death occurs within 48 hours after the breathing tube is removed. The current status of this study is unclear.

Study design
This study plans to enroll 880 participants and compares two different methods of breathing support during a spontaneous breathing trial.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Researchers will check for reintubation or death within 48 hours of your breathing tube being removed.

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NCT07005505

Automatic Tube Compensation vs. Pressure Support Ventilation During Spontaneous Breathing Trials in Adults

Recruiting
NAAges 18+Interventional
Rush University Medical Center
~880 participants
Updated 2026-07-02 on ClinicalTrials.gov
What's tested:Pressure Support Ventilation (PSV)Automatic tube compensation (ATC)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Reintubation
Measured over Within 48 hours of extubation
+1 more outcome measured
Spontaneous Breathing Trial in ICU
1 sites across 1 states
Illinois1

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Eligibility criteria

Inclusion

Admitted to intensive care unit (ICU)
Age 18 years or older
Requiring invasive mechanical ventilation for at least 24 hours
Pass spontaneous breathing trial screen criteria

Exclusion

Clinical decision made not to proceed with extubation regardless of spontaneous breathing trial (SBT) results
Do not intubate (DNI) order
Presence of tracheostomy
Pregnancy
Known prisoner
Immediate need for extubation, self-extubation, or unplanned extubation that precludes safe performance of study procedures
Enrolled in another clinical trial that impacts ventilator weaning or liberation
  • ReintubationWithin 48 hours of extubation
  • DeathWithin 48 hours of extubation