REACH Study: Community Mental Health for Schizophrenia and Related Conditions
The REACH Study is looking at how two types of community mental health care affect thinking abilities, daily functioning, and brain activity in adults with schizophrenia, schizoaffective disorder, or schizophreniform disorders. You might be eligible if you are 18-50 years old, have one of these diagnoses, and are stable on your current psychiatric medication. This study compares the Clubhouse Model of Psychosocial Rehabilitation, which is a supportive community approach, with Usual Community-Based Mental Health Care. Researchers will measure changes in your overall thinking performance, how well you manage daily life, and your quality of life over six months to see which approach is more helpful. The study aims to enroll 30 participants, but its current recruitment status is unclear.
- Study design
- This interventional study plans to enroll 30 participants. It compares two behavioral interventions: the Clubhouse Model of Psychosocial Rehabilitation and Usual Community-Based Mental Health Care.
- What's involved
- If you join, you will have six study visits with the research team: three at the beginning and three more six months later.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your cognitive performance, functional outcome, and quality of life will be measured at baseline and again at 6 months.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
REACH Study (Recovery Environments: Assessing Cognitive & Brain Health in Community Mental Health)
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Jessica A Wojtalik, PhD · PRINCIPAL_INVESTIGATOR · Case Western Reserve University
Who to contact
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Do you actually qualify for this trial?
Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.
Inclusion
Exclusion
What this trial measures
- Change in overall cognitive performance as measured by MATRICS Consensus Cognitive Battery (MCCB)Baseline and 6 months
The MATRICS Consensus Cognitive Battery (MCCB), which was developed by NIMH as a standardized assessment tool as an outcome measure of cognitive change in intervention trials. This performance-based battery contains 10 field standard, individually administered computer and paper-and-pencil tests of neurocognition (processing speed, attention, working memory, verbal learning, visual learning, and problem solving) and social cognition. The MCCB takes approximately 60-90 minutes to administer. The overall composite score (M = 50, SD = 10) with higher scores indicated better cognitive performance.
- Change in functional outcome as measured by Specific Levels of Functioning Scale (SLOF)Baseline and 6 months
The SLOF is a 30-item self-and/or informant-report measure of interpersonal relationships, social acceptability, community activities, and living and work skills rated on a 5-point scale, with higher scores reflecting better functional outcome.
- Change in quality of life as measured by World Health Organization Quality of Life Brief Assessment (WHOQOL-BREF)Baseline and 6 months
The WHOQOL-BREF is a 26-item quality of life (QoL) measure developed by the World Health Organization of physical health, psychological, social relationships, and environment QoL. Items are rated on a 5-point scale, with higher scores reflecting better QoL.
- Change in disability as measured by the 12-item WHO Disability Assessment Schedule 2.0 (WHODAS 2.0Baseline and 6 months
A brief (12-item), universal interviewer/self-report measure of functional disability that assesses 6 areas (mobility, life activities, cognition, participation, self-care, getting along with others) rated on level of difficulty in the past 30 days with higher scores indicating more disability.
- Change in task-based brain activation during functional MRI (fMRI) as measured by the AX-Continuous Performance Task (AX-CPT)Baseline and 6 months
An NIMH validated fMRI task of goal maintenance (attention) in schizophrenia. This task implements the "A-then-X rule" where participants are instructed to make an index finger button press only when "A" precedes "X" (target trial, 72%) and a middle finger press for all other "non-target" trials (AY: 11%; BX: 11%; BY: 6%) for a total of 4 blocks of 36 trials (144 total). Trials are presented for 500ms followed by a cue (+) presentation for 1000ms (target or non-target response expected) with an interstimulus interval of 2000ms. Instructions and practice trials are embedded. The main contrast of interest for group-level analyses is the high vs. low cognitive load trials (cue A \> cue B), with greater fronto-limbic brain activation during high cognitive load indicating strong attention-related brain activation.
- Change in task-based brain activation during functional MRI (fMRI) as measured by the Emotional Faces N-Based Task (EFNBACK)Baseline and 6 months
A modified version of the standard working memory n-back task. This task includes 8 blocks (4 are 0-back and 4 are 2-back) of 12 trials. Each block starts with instructions indicating the condition (0-back or 2-back) presented for 3500ms, which is followed by the target stimulus (letters) flanked by emotional valence distractor conditions (happy, fearful, neutral, or no face) for 500ms, with an interstimulus interval jittered at an average of 3500ms. Blocks with emotional vs. no distractors are randomly interspersed throughout. The main contrasts of interest for group-level analyses are working memory load (2-back \> 0-back) and emotion distractor conditions (happy \> neutral; fearful \> neutral), with greater activation during the 2-back and emotional distractor conditions indicating better working memory and emotion regulation brain functioning.