Back to search results

Smart Olfaction App to Reduce Relapse for Nicotine Dependence

This study is testing a new way to help people quit smoking by combining a special smell device called Inspire with a smartphone app called Smart-T. Participants will use the Inspire device, which delivers a specific scent designed to help with smoking cessation, either on their own or at instructed times. Some participants will also use the Smart-T app, which provides support and information for quitting. Others will use the Smart-T app without the Inspire device. Nicotine replacement therapy (NRT) patches will also be provided to help with cravings. The study aims to see if using the Inspire device with the Smart-T app is more effective at helping people quit smoking compared to using the app alone. You may be able to join if you are at least 18 years old, smoke at least 5 cigarettes daily, and have a smartphone. The study's current status is unclear.

Study design
This is an interventional study with a planned enrollment of 132 participants. It will involve different groups using the Inspire device, the Smart-T app, or both, along with nicotine replacement therapy.
What's involved
Participants will use the Inspire device for 7 days in different ways. They will also complete surveys, daily check-ins, and potentially a qualitative interview.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 12 weeks after their quit date to assess craving reduction.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07007195

Smart Olfaction App to Reduce Relapse

Recruiting
EARLY_PHASE1Ages 18+InterventionalTreatment
University of Houston
~132 participants
Updated 2026-07-08 on ClinicalTrials.gov
What's tested:Ad Libitum Use followed by Instructed Use of the Inspire DeviceInstructed Use followed by Ad Libitum Use of the Inspire DeviceSmart-T Smoking Cessation App with the Inspire Device ConditionSmart-T Smoking Cessation App Without the Inspire Device ConditionNicotine replacement therapy (NRT)Inspire Device

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
OSDS Use
Measured over Phase I: Post randomization to End of Study (14 days post-quit date)
+4 more outcomes measured

Conditions

Nicotine Dependence

Explore related trials

Nicotine Dependence

Where it's being run

1 sites across 1 states
Texas1

Study leadership

  • Lorra Garey, Ph.D. · PRINCIPAL_INVESTIGATOR · University of Houston
  • Michael Businelle, Ph.D. · PRINCIPAL_INVESTIGATOR · University of Oklahoma Health Sciences
  • Michael Sayette, Ph.D. · PRINCIPAL_INVESTIGATOR · University of Pittsburgh

Who to contact

Lorra Garey, Ph.D.
[email protected]
713-743-8056
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

At least 18 years of age
Ability to read, understand and speak English
Currently smoke at least 5 cigarettes daily for one year or longer
Do not currently smoke marijuana or currently smoke marijuana but willing to not smoke during the duration of the study
Did not use electronic cigarette or vaping device in the past 90 days
Have an active smartphone that is Apple or Android based
Have phone service including a data plan
Interested in downloading the study app onto their personal phone
Motivated to quit smoking
English literacy of 7th grade or higher, as indicated by a score of ≥ 4 on the Rapid Estimate of Adult Literacy in Medicine-Short Form (REALM-SF)
Biochemical verification of smoking status
Proof of smoking status at enrollment via photo of cigarettes
Presents a photo ID that matches the information on screener survey
Willing and able to complete study procedures
Willing to use NRT and quit smoking for 14 days (Phase I) or willing to use NRT and quit smoking for 13 weeks (Phase II)

Exclusion

Olfactory dysfunction including inability to smell, a very weak or distorted sense of smell, or sensitivity to odors
Report any allergies or negative reactions to odors/fragranced products
Being pregnant, breastfeeding, or planning to become pregnant within the next month
Report hypertension that is not under control
Have had a heart attack within the past two weeks
Those who participated in Phase I will not be eligible to participate in Phase II
Have a smartphone that is not compatible with the Insight mHealth platform
Report using electronic cigarette or vaping device in the past 90 days

What this trial measures

  • OSDS UsePhase I: Post randomization to End of Study (14 days post-quit date)

    Descriptive data regarding use times and frequency will be assessed.

  • Odor AssessmentPhase I: Post randomization to End of Study (14 days post-quit date)

    Reports of odor assessment will be used to determine if sniffing specific odors reduce craving more than an odor blank.

  • Craving ReductionPhase I: Post randomization to End of Study (14 days post-quit date). Phase II: Post randomization to End of Study (12 weeks post-quit date)

    Participants will report craving levels multiple times per day via the app. Reduction in craving levels over time will be analyzed.

  • Device AcceptabilityPhase I: End of Study (14 days post-quit date). Phase II: End of Study (12 weeks post-quit date)

    Participant satisfaction ratings and qualitative feedback. Acceptability will be assessed through post-intervention surveys and qualitative interviews, focusing on perceived usefulness, ease of use, and overall satisfaction.

  • Smoking AbstinencePhase II: Randomization to End of Study

    Biochemically confirmed 7-day point prevalence abstinence 12 weeks following the scheduled quit day.